动脉粥样硬化是导致多种心血管疾病的重要原因。目前临床治疗动脉粥样硬化的药物包括降脂药物、抗血小板药、降压药物、血管扩张剂等。丹皮酚具有多种活性，可通过减轻炎症反应、减轻氧化应激反应、抑制血管内皮细胞凋亡、抑制内皮–间充质转化进程、恢复血管平滑肌细胞活性、调节血脂、减轻脂质积累、改善血液流变学发挥防治动脉粥样硬化的作用。总结了丹皮酚抗动脉粥样硬化的药理作用研究进展，为丹皮酚治疗动脉粥样硬化的应用提供参考。

Atherosclerosis is an important cause of many cardiovascular diseases. At present, the drugs for clinical treatment of atherosclerosis include lipid-lowering drugs, antiplatelet drugs, antihypertensive drugs, vasodilators, etc. Paeonol has various activities, which can prevent and treat atherosclerosis by alleviating inflammatory response, reducing oxidative stress response, inhibiting endothelial cell apoptosis, suppressing endothelial-mesenchymal transition process, restoring vascular smooth muscle cell activity, regulating blood lipids, reducing lipid accumulation, and improving hemorheology. This article summarized the research progress of the pharmacological effects of paeonol against atherosclerosis, providing a reference for the application of paeonol in treatment of atherosclerosis.

R285.5;R972

潍坊市科技发展计划项目（WFWSJK-2023-322）