成骨细胞是骨代谢中主导骨形成的主要功能细胞，对骨骼的生长、骨平衡的维持至关重要。成骨细胞分化受多条信号通路的调控，如Wnt/β-连环蛋白、骨形态发生蛋白/Smad、丝裂原活化蛋白激酶、Hedgehog通路，这些通路的异常激活或抑制均可能导致骨形成失衡，而中药成分可通过靶向调控这些信号通路的关键分子发挥促成骨效应。综述了中药成分调控信号通路促进成骨细胞分化的研究进展，总结其作用机制和潜在应用价值，为骨质疏松症等骨代谢疾病的药物研发提供参考。

Osteoblasts are the main functional cells that dominate bone formation in bone metabolism and are crucial for bone growth and maintenance of bone balance. Osteoblast differentiation is regulated by multiple signaling pathways, such as Wnt/β-catenin, BMP/Smad, MAPK, and Hedgehog signaling pathway. Abnormal activation or inhibition of these signaling pathways may lead to imbalanced bone formation, and traditional Chinese medicine components can promote bone effects by targeting key molecules in these signaling pathways. This article reviews the research progress on the regulation of signaling pathways by traditional Chinese medicine components to promote osteoblast differentiation, summarizes its mechanism and potential application value, and provides reference for drug development of bone metabolism diseases such as osteoporosis.

R285.5

云南省社科联-云南中医药大学联合专项（LHZX202423）；云南省科技人才与平台计划（院士专家工作站）（202305AF150151）