心血管疾病是全球范围内致死、残疾的主要原因之一，口服抗血小板药物在预防和治疗心血管疾病方面发挥不可替代的作用。口服抗血小板药物临床应用面临出血风险、药物抵抗、个体差异、长期治疗的依从性的挑战，需要制定应对挑战的策略。总结了常见的口服抗血小板药物治疗心血管疾病的作用机制和临床应用，探讨了面临的挑战，介绍了应对策略，旨在为合理使用口服抗血小板药物，提高治疗效果，降低不良反应提供参考。

Cardiovascular disease is one of the leading causes of death and disability worldwide, and oral antiplatelet drugs play an irreplaceable role in prevention and treatment of cardiovascular disease. The clinical application of oral antiplatelet drugs faces challenges such as bleeding risk, drug resistance, individual differences, and compliance with long-term treatment, and needs to develop strategies to address challenges. This article summarizes the mechanisms and clinical applications of common oral antiplatelet drugs in treatment of cardiovascular diseases, explores the challenges faced, and introduces coping strategies, aiming to provide reference for the rational use of oral antiplatelet drugs, improve treatment efficacy, and reduce adverse reaction.

R972

内蒙古自治区自然科学基金项目（2024LHMS08027）