目的 探讨鱼腥草滴眼液联合更昔洛韦眼用凝胶治疗流行性角结膜炎的临床疗效。方法 选取2022年4月—2025年3月在郑州大学第二附属医院就诊的86例流行性角结膜炎患者，所有患者按随机数字表法分为对照组和治疗组，每组各43例。对照组将更昔洛韦眼用凝胶涂入结膜囊中，4次/d，每次8 mm。治疗组患者在对照组基础上使用鱼腥草滴眼液滴眼，6次/d，每次1滴。两组患者持续治疗10 d。比较两组临床疗效、症状消失时间、视力、病情程度、泪液指标。结果 治疗组总有效率为95.35%，对照组总有效率为79.07%，组间比较差异显著（P＜0.05）。治疗组患者疼痛、流泪、畏光、红肿消失时间均短于对照组（P＜0.05）。两组治疗后的视力明显升高，眼表疾病指数量表（OSDI）评分明显降低（P＜0.05）；治疗组治疗后的视力高于对照组，OSDI评分低于对照组（P＜0.05）。两组治疗后泪液乳铁蛋白、黏蛋白5AC显著升高（P＜0.05），治疗组治疗后的泪液乳铁蛋白、黏蛋白5AC高于对照组（P＜0.05）。结论 鱼腥草滴眼液联合更昔洛韦眼用凝胶可提高流行性角结膜炎的临床疗效，改善临床症状和视力，减轻病情严重程度，与降低结膜炎性损伤有关。

Objective To explore the clinical efficacy of Yuxingcao Eye Drops combined with Ganciclovir Ophthalmic Gel in treatment of epidemic keratoconjunctivitis. Methods A total of 86 patients with epidemic keratoconjunctivitis who visited Zhengzhou University Second Affiliated Hospital from April 2022 to March 2025 were selected. All patients were divided into control group and treatment group using a random number table method, with 43 patients in each group. The patients in the control group were treated with Ganciclovir Ophthalmic Gel applied into the conjunctival sac, 4 times daily, 8 mm each time. On the basis of the control group, the patients in the treatment group were treated with Yuxingcao Eye Drops, 6 times daily, 1 drop each time. Two groups of patients were treated continuously for 10 d. The clinical efficacy, symptom disappearance time, visual acuity, disease severity, and tear indicators were compared between two groups. Results The total effective rate of the treatment group was 95.35%, while the total effective rate of the control group was 79.07%, and the difference was significant between two groups (P < 0.05). The disappearance times of pain, tears, photophobia, and redness in the treatment group was shorter than those in the control group (P < 0.05). The visual acuity of two groups were significantly improved after treatment, but the OSDI score were significantly decreased (P < 0.05). The visual acuity of the treatment group was higher than that of the control group after treatment, but the OSDI score was lower than that of the control group (P < 0.05). After treatment, the levels of lactoferrin and mucin 5AC in tears significantly increased in two groups (P < 0.05). The levels of lactoferrin and mucin 5AC in the tears of the treatment group were higher than those of the control group after treatment (P < 0.05). Conclusion Yuxingcao Eye Drops combined with Ganciclovir Ophthalmic Gel can improve the efficacy of epidemic keratoconjunctivitis, improve clinical symptom and vision, and reduce the severity of the disease, which is related to reducing conjunctival inflammatory damage.

R988.1

河南省医学科技攻关计划项目（LHGJ20190323）