目的 观察金花消痤丸联合克林霉素甲硝唑搽剂治疗玫瑰痤疮的临床疗效。方法 纳入衡水市人民医院2022年4月—2024年2月收治的玫瑰痤疮患者100例，采用随机数字表法将患者分为对照组和治疗组，各50例。对照组患处外用克林霉素甲硝唑搽剂，每日早晚各1次，待药液干燥后全面部涂医用愈肤生物膜。治疗组在对照组的基础上口服金花消痤丸，1袋/次，3次/d。两组疗程均为4周。比较两组的临床疗效、临床症状积分、皮肤生理指标、生活质量、血清因子。结果 治疗组的总有效率为94.00%，高于对照组的总有效率76.00%（P＜0.05）。治疗后，两组潮红斑评分、毛细血管扩张评分、丘疹和脓疱评分下降（P＜0.05），且治疗组潮红斑评分、毛细血管扩张评分、丘疹和脓疱评分低于对照组（P＜0.05）。治疗后，两组表皮水分流失量、皮肤油脂量下降，皮肤角质层含水量升高（P＜0.05），且治疗组表皮水分流失量、皮肤油脂量低于对照组，皮肤角质层含水量高于对照组（P＜0.05）。治疗后，两组玫瑰痤疮生活质量量表（RosaQoL）评分下降（P＜0.05），且治疗组RosaQoL评分低于对照组（P＜0.05）。治疗后，两组血清C反应蛋白（CRP）、白细胞介素（IL）-37、IL-17A、IL-6、肿瘤坏死因子-α（TNF-α）水平下降（P＜0.05），治疗组血清CRP、IL-37、IL-17A、IL-6、TNF-α水平低于对照组（P＜0.05）。结论 金花消痤丸联合克林霉素甲硝唑搽剂治疗玫瑰痤疮可有效改善临床症状，提高生活质量，降低炎症因子水平。

Objective To observe the clinical efficacy of Jinhua Xiaocuo Pills combine with Clindamycin Hydrochloride and Metronidazole Liniment in treatment of rosacea. Methods A total of 100 patients with rosacea admitted to Hengshui People’s Hospital from April 2022 to February 2024 were divided into control group and treatment group using a random number table method, with 50 patients in each group. The control group applied Clindamycin Hydrochloride and Metronidazole Liniment topically to the affected area, once in the morning and once in the evening. After the medicine was dried, the entire area was coated with a medical healing biofilm. The treatment group took Jinhua Xiaocuo Pills orally on the basis of the control group, 1 bag/time, 3 times daily. The treatment course for two groups was 4 weeks. The clinical efficacy, clinical symptom score, skin physiological index, quality of life, and serum factors were compared between two groups of patients. Results The total effective rate of the treatment group was 94.00%, which was higher than the total effective rate of 76.00% in the control group (P < 0.05). After treatment, the scores of erythema, telangiectasia, papules, and pustules in two groups decreased (P < 0.05), and the scores of erythema, telangiectasia, papules, and pustules in the treatment group were lower than those in the control group (P < 0.05). After treatment, the loss of epidermal water and the amount of skin oil decreased in two groups, while the moisture content of the stratum corneum increased (P < 0.05). Moreover, the loss of epidermal water and the amount of skin oil in the treatment group were lower than those in the control group, while the moisture content of the stratum corneum was higher than that in the control group (P < 0.05). After treatment, the RosaQoL scores of two groups decreased (P < 0.05), and the RosaQoL score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the serum levels of C-reactive protein (CRP), interleukin-37 (IL-37), IL-17A, IL-6, and tumor necrosis factor-α (TNF-α) decreased in two groups (P < 0.05), and the serum levels of CRP, IL-37, IL-17A, IL-6, and TNF-α in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Jinhua Xiaocuo Pills combine with Clindamycin Hydrochloride and Metronidazole Liniment in treatment of rosacea can effectively improve clinical symptoms, enhance quality of life, and reduce levels of inflammatory factors.

R986

衡水市科技计划项目（2021014078Z）