目的 研究乐孕宁颗粒联合烯丙雌醇治疗习惯性流产的临床效果。方法 选取2022年3月—2023年11月西北妇女儿童医院收治的习惯性流产患者204例，随机分为对照组和治疗组，每组各102例。对照组口服烯丙雌醇片，10 mg/次，1次/d。治疗组在对照组基础上口服乐孕宁颗粒，5 g/次，3次/d。两组患者均治疗至妊娠第5个月末。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间、性激素水平、血清炎症因子水平和保胎成功率。结果 治疗后，治疗组总有效率高于对照组（90.20% vs 82.35%，P＜0.05）。治疗组阴道出血、下腹坠胀和腰酸腹痛症状缓解时间均明显短于对照组（P＜0.05）。治疗后，两组人绒毛膜促性腺激素β（β-HCG）、雌二醇（E₂）、孕酮（P）水平均较治疗前显著升高（P＜0.05），且治疗组各项性激素指标水平高于对照组（P＜0.05）。治疗后，两组患者C反应蛋白（CRP）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）水平较治疗前显著降低（P＜0.05），治疗组各项炎症指标水平低于对照组（P＜0.05）。治疗后，治疗组保胎成功率为92.16%，明显高于对照组的81.37%，两组比较差异具有统计学意义（P＜0.05）。结论 乐孕宁颗粒联合烯丙雌醇对习惯性流产有良好应用，可促进症状消退，改善激素水平，降低血清炎症因子水平，提高患者的保胎成功率。

Objective To study the clinical effect of Leyunning Granules combined with allylestrenol in treatment of habitual abortion. Methods Patients (204 cases) with habitual abortion in Northwest Women′s and Children′s Hospital from March 2022 to November 2023 were randomly divided into control and treatment group, and each group had 102 cases. Patients in the control group were po administered with Allylestrenol Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Leyunning Granules on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated until the end of the 5th trimester. After treatment, the clinical evaluations were evaluated, and the symptom relief time, serum sex hormone levels, inflammatory indicators levels and rate of fetal protection in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was higher than that of the control group (90.20% vs 82.35%, P < 0.05). The relief time of vaginal bleeding, lower abdominal distension and lumbago and abdominal pain symptoms in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, the levels of β-HCG, E₂, and P in both groups were significantly increased compared with those before treatment (P < 0.05), and the levels of various sex hormone indicators in treatment group were higher than those in control group (P < 0.05). After treatment, the levels of CRP, IL-8, and TNF-α in both groups were significantly lower than those before treatment (P < 0.05), and the levels of various inflammatory indicators in treatment group were lower than those in control group (P < 0.05). After treatment, the success rate of maintaining pregnancy in treatment group was 92.16%, significantly higher than 81.37% in control group. The difference between the two groups was statistically significant (P< 0.05). Conclusion Leyunning Granules combined with Allylestrenol Tablets has good clinical efficacy in the treatment of habitual abortion, which can alleviate various symptoms, increase the level of sex hormones, reduce the level of serum inflammatory factors, improve the success rate of fetal protection.

R984

陕西省重点研发计划项目（2021SF-040）