目的 探讨骨松宝颗粒联合唑来膦酸注射液治疗股骨粗隆间骨折的效果。方法 将2022年3月—2025年2月在沧州市人民医院就诊的80例股骨粗隆间骨折患者作为研究对象，按随机数字表法将患者分为对照组和治疗组，每组各40例。对照组静滴唑来膦酸注射液，每4周1次，每袋至少滴注15 min。治疗组在对照组基础上口服骨松宝颗粒，3次/d，1袋/次。4周为1个疗程，两组持续治疗3个疗程。比较两组患者的治疗效果、疼痛程度、关节功能、骨密度、血清指标。结果 治疗组、对照组的总有效率分别为97.50%、85.00%，组间比较差异有统计学意义（P＜0.05）。两组治疗后的视觉模拟评分法（VAS）评分明显降低，髋关节功能（Harris）评分明显升高（P＜0.05）；治疗组治疗后的VAS评分低于对照组，Harris评分高于对照组（P＜0.05）。两组治疗后的股骨粗隆、股骨颈骨密度均显著升高（P＜0.05），且治疗组的股骨粗隆、股骨颈骨密度高于对照组（P＜0.05）。两组治疗后的血清骨形态发生蛋白-2（BMP-2）水平升高，血清肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）水平降低（P＜0.05）；治疗组治疗后的血清BMP-2水平高于对照组，血清TNF-α、IL-10水平低于对照组（P＜0.05）。结论 骨松宝颗粒联合唑来膦酸注射液可提高股骨粗隆间骨折的治疗效果，减轻疼痛程度，提高关节功能和骨密度，减轻炎症反应。

Objective To investigate the therapeutic effect of Gusongbao Granules combined with Zoledronic Acid Injection in treatment of intertrochanteric fractures of the femur. Methods A total of 80 patients with intertrochanteric fractures of the femur treated at Cangzhou People's Hospital from March 2022 to February 2025 were selected as the research subjects. The patients were randomly divided into control group and treatment group using the random number table method, with 40 cases in each group. The control group received intravenous Zoledronic Acid Injection once every 4 weeks for at least 15 min per bag. The treatment group took orally Gusongbao Granules on the basis of the control group, 3 times daily, 1 bag/time. Four weeks was one course of treatment, and two groups of patients receive continuous treatment for three courses. The treatment efficacy, pain level, joint function, bone density, and serum indicators were compared between two groups of patients. Results The total effective rates of the treatment group and the control group were 97.50% and 85.00%, respectively, and the difference was statistically significant between two groups (P < 0.05). After treatment, the visual analogue scale (VAS) scores were significantly decreased, but the hip joint function (Harris) scores were significantly increased in two groups (P < 0.05). The VAS score of the treatment group was lower than that of the control group after treatment, but the Harris score was higher than that of the control group (P < 0.05). The bone density of the femoral trochanter and femoral neck significantly increased in two groups after treatment (P < 0.05), and these indexes in the treatment group was higher than those in the control group (P < 0.05). After treatment, the serum levels of bone morphogenetic protein-2 (BMP-2) increased in two groups, while the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) decreased (P < 0.05). The serum levels of BMP-2 in the treatment group were higher than those in the control group after treatment, while the serum levels of TNF-α and IL-10 were lower than those in the control group (P < 0.05). Conclusion The combination of Gusongbao Granules and Zoledronic Acid Injection can improve the therapeutic effect of intertrochanteric fractures of the femur, reduce pain, improve joint function and bone density, alleviate inflammatory reactions.

R982

河北省医学科学研究课题计划（20220320）