目的 探讨槐杞黄颗粒联合西咪替丁治疗儿童IgA血管炎的临床疗效。方法 选取2020年1月1日—2022年12月31日成都儿童专科医院收治的120例IgA血管炎患儿，按照计算机随机排列法将所有患儿分为对照组（60例）与治疗组（60例）。对照组静滴西咪替丁注射液，每次5 mg/kg，2次/d。治疗组在对照组的基础上温水冲服槐杞黄颗粒，1袋/1次，2次/d。两组患儿分别连续治疗2周。观察两组患儿的临床疗效和症状消失时间，比较两组治疗前后肾功能、生化指标、血清免疫指标的变化。结果 治疗组的总有效率（93.33%）高于对照组（80.00%，P＜0.05）。治疗后，治疗组皮肤紫癜消失时间、关节痛消失时间、腹痛消失时间显著短于对照组（P＜0.05）。治疗后，两组血肌酐（Scr）、24 h尿蛋白量、尿沉渣红细胞计数低于治疗前（P＜0.05）；治疗组患儿Scr、24 h尿蛋白量、尿沉渣红细胞计数低于对照组（P＜0.05）。治疗后，两组IgA水平均比治疗前低，IgM、IgG比治疗前高（P＜0.05）；治疗组患儿的IgA水平比对照组低，IgM、IgG比对照组高（P＜0.05）。结论 槐杞黄颗粒联合西米替丁治疗儿童IgA血管炎具有较好的疗效，缩短症状消失时间，调节患儿的免疫状态，值得临床进行推广。

Objective To investigate the clinical efficacy of Huaiqihuang Granules combined with cimetidine in treatment of IgA vasculitis in children. Methods A total of 120 children with IgA vasculitis admitted to Chengdu Children’s Specialized Hospital from January 1, 2020 to December 31, 2022 were selected. All children were divided into control group (60 cases) and treatment group (60 cases) according to the computer random arrangement method. Patients in control group received intravenous infusion of Cimetidine Injection at a dose of 5 mg/kg each time, twice daily. Patients in treatment group took Huaiqi Huang Granules dissolved in warm water on basis of control group, 1 bag once, twice daily. The two groups of children were treated continuously for two weeks respectively. The clinical efficacy and symptom disappearance time of two groups were observed, and the changes of renal function, biochemical indicators and serum immune indicators before and after treatment in two groups were compared. Results The total effective rate of the treatment group (93.33%) was higher than that of the control group (80.00%, P < 0.05). After treatment, the disappearance time of skin purpura, joint pain and abdominal pain in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, the levels of Scr, 24 h urine protein quantity and urine sediment red blood cell count in both groups were lower than those before treatment (P < 0.05). The levels of Scr, 24 h urine protein quantity and urine sediment red blood cell count of the children in treatment group were lower than those in control group (P < 0.05). After treatment, the IgA levels in both groups were lower than those before treatment, but IgM and IgG were higher than those before treatment (P < 0.05). The IgA level of children in treatment group was lower than that in control group, but IgM and IgG levels were higher than those in control group (P < 0.05). Conclusion The combination of Huaiqi Huang Granules and cimetidine in treatment of IgA vasculitis in children has a good therapeutic effect, shortens the disappearance time of symptoms, and regulates the immune status of children, which is worthy of clinical promotion.

R976