目的 探讨有机阳离子转运蛋白1（OCT1）（rs622342）和多药及毒素外排转运蛋白1（MATE1）（rs2289669）基因多态性对接受二甲双胍治疗的2型糖尿病患者血糖控制指标的影响。方法 采用横断面研究方法，所有确诊为2型糖尿病的参与者接受盐酸二甲双胍片1～2 g/d治疗至少3个月，记录血糖控制水平、代谢指标，并测定OCT1和MATE1基因型，使用IBM SPSS Statistics for Windows V22.0统计分析不同基因型与患者血糖控制水平、代谢指标之间的相关性。结果 共纳入191名2型糖尿病的患者。MATE1（rs2289669）AA/AG基因型携带者的空腹血糖（FPG）水平显著低于GG基因型患者，高密度脂蛋白胆固醇（HDL-C）水平比GG型显著升高。Logistics回归结果发现，MATE1（rs2289669）对于FPG、身体质量指数（BMI）和HDL-C有统计学意义。交互作用模型分析发现，在FPG中，同时拥有OCT1（rs622342）AA型和MATE1（rs228966）GG型基因的患者具有明显的交互作用且为协同作用，无明显相乘作用。结论 OCT1和MATE1基因多态性与接受二甲双胍治疗的2型糖尿病患者血糖控制有显著关联，在与FPG相关性方面存在协同效应，也与脂代谢和BMI有关。OCT1和MATE1基因多态性可能在二甲双胍治疗2型糖尿病患者血糖控制和代谢指标方面具有预测作用。

Objective To investigate the effect of organic cation transporter 1 (OCT1) (rs622342) and multidrug and toxin efflux transporter 1 (MATE1) (rs2289669) gene polymorphisms on blood glucose indicators in type 2 diabetes patients treated with metformin. Methods Using the cross-sectional study method, all participants diagnosed with type 2 diabetes were treated with Metformin Hydrochloride Tablets 1 — 2 g/d for at least three months, the blood glucose control level and metabolic indicators were recorded, and the OCT1 and MATE1 genotypes were determined. Statistical analyses were performed using IBM SPSS Statistics for Windows V22.0 to analyze the correlation between different genotypes and patients' blood glucose levels and metabolic indicators. Results A total of 191 patients with type 2 diabetes were included. The fasting blood glucose (FPG) level of MATE1 (rs2289669) AA/AG genotype carriers was significantly lower than that of GG genotype patients, but the high-density lipoprotein cholesterol (HDL-C) level was significantly higher than that of GG genotype patients. The logistics regression results showed that MATE1 (rs2289669) had statistical significance for FPG, body mass index (BMI), and HDL-C. The interaction model analysis showed that patients with both OCT1 (rs622342) AA and MATE1 (rs228966) GG genes in FPG exhibited significant interaction and synergistic effects, with no significant multiplicative effects. Conclusion The polymorphism of OCT1 and MATE1 genes is significantly associated with the blood glucose of type 2 diabetes patients treated with metformin. There is a synergistic effect in the correlation with FPG, and it is also associated with lipid metabolism and BMI levels. The polymorphism of OCT1 and MATE1 genes may have a predictive role in the blood glucose and metabolic indicators of type 2 diabetes patients treated with metformin.

R968;R977

山东省药品临床综合评价项目（2024YZ002）；济南市科技计划项目（201602171）