药物再利用能极大地节约药物发现过程中的时间和经济成本，可以有效降低失败风险。已经出现耐药性的抗生素类药物左氧氟沙星、苯唑西林、多西环素、阿奇霉素通过药物再利用挖掘，重新应用在非感染性疾病的治疗，如肺癌、阿尔茨海默病、疟疾、新型冠状病毒感染，有效提高此类药物的应用潜能。描述了抗生素类药物的药物再利用情况，分析其潜在风险以及潜在风险评估面临的困难，为抗生素类药物的药物再利用提供新的思路和更加安全有效的研究方案。

Drug reuse can greatly save time and economic costs in the drug discovery process, and can effectively reduce the risk of failure. The antibiotic drugs levofloxacin, oxacillin, doxycycline and azithromycin that have emerged resistance are re-used in treatment of non-infectious diseases, such as lung cancer, Alzheimer's disease, malaria, and novel coronavirus infection, effectively improving the application potential of these drugs. This article describes the drug reuse of antibiotic drugs, analyzes their potential risks and the difficulties faced in risk assessment, and provides new ideas and safer and more effective strategies for drug reuse of antibiotic drugs.

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