阿尔茨海默病是最常见的神经退行性疾病，而沉默信息调节因子1（Sirt1）具有作为阿尔茨海默病治疗靶点的潜力。多酚类化合物是植物次生代谢产物，可通过调节Sirt1抑制β-淀粉样蛋白（Aβ）蛋白生成、抑制Tau蛋白磷酸化、抗氧化应激、抑制神经炎症、增强突触可塑性、增强细胞自噬、抑制神经元凋亡，达到改善阿尔茨海默病。综述了多酚类化合物通过调节Sirt1活性改善阿尔茨海默病的分子机制，为开发基于天然产物的阿尔茨海默病干预策略提供参考。

Alzheimer's disease is the most common neurodegenerative disease, and silent information regulatory factor 1 (Sirt1) has the potential to be a therapeutic target for treatment of Alzheimer's disease. Polyphenolic compounds are the secondary metabolites in plants that can improve Alzheimer's disease by regulating Sirt1 to inhibit the production of β-amyloid (Aβ) protein, suppress Tau protein phosphorylation, resist oxidative stress, suppress neuroinflammation, enhance synaptic plasticity, enhance autophagy, and inhibit neuronal apoptosis. This article reviews the molecular mechanisms of polyphenolic compounds in improving Alzheimer's disease by regulating Sirt1, to provid reference for the development of natural product based intervention strategies for treatment of Alzheimer's disease.

R285.5;R971

陕西省重点研发计划项目（2023-YBSF-152）