目的 探讨西吡氯铵含片联合米诺环素软膏治疗种植体周围炎的临床疗效。方法 选取2022年10月—2024年11月唐山职业技术学院附属医院收治的98例患者，依据随机数字法分为对照组和治疗组，每组各49例。对照组患者牙周袋内注满米诺环素软膏，禁食1 h，１次/周。在对照组的基础上，治疗组口服西吡氯铵含片，1片/次，4次/d。两组患者均连续治疗14 d。观察两组患者临床疗效，比较治疗前后两组患者菌斑指数评分（PLI）、龈沟出血指数评分（SBI）、牙龈指数评分（GI）评分，龈沟液中白细胞介素-1β（IL-1β）、黏蛋白-4（MUC-4）、肿瘤坏死因子-α（TNF-α）和基质金属蛋白酶-7（MMP-7）水平。结果 治疗后，治疗组总有效率（97.96%）明显高于对照组的总有效率（81.63%，P＜0.05）。治疗后，两组患者PLI、GI、SBI评分比治疗前明显下降（P＜0.05），且治疗后，与对照组对比，治疗组PLI、GI、SBI评分下降更明显（P＜0.05）。治疗后，两组龈沟液中IL-1β、TNF-α、MMP-7水平比治疗前明显降低，而且MUC-4水平明显升高（P＜0.05），且治疗后，治疗组IL-1β、TNF-α、MMP-7和MUC-4水平明显好于对照组（P＜0.05）。结论 西吡氯铵含片与米诺环素软膏协同治疗种植体周围炎疗效显著，能减轻机体炎症损伤，有效改善牙周健康状况。

Objective To explore the clinical effect of cetylpyridinium chloride combined with minocycline in treatment of peri-implantitis. Methods Patients (98 cases) with peri-implantitis in Affiliated Hospital of Tangshan Vocational and Technical College from October 2022 to November 2024 were divided into control and treatment group according to the random number method, and each group had 49 cases. Patients in the control group were administered with Minocycline Hydrochloride Ointment in periodontal pockets, fasting for 1 h, once weekly. Patients in the treatment group were po administered with Cetylpyridinium Chloride Buccal Tablets on the basis of the control group, 1 tablet/time, four times daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluations were evaluated, and the scores of PLI, GI and SBI, the levels of IL-1β, TNF-α, MMP-7 and MUC-4 of gingival crevicular fluid in two groups before and after treatment were compared. Results After treatment, the effective rate of the treatment group (97.96%) was significantly higher than that of the control group (81.63%, P < 0.05). After treatment, the PLI, GI, and SBI scores in two groups were significantly decreased compared to before treatment (P < 0.05), and compared with the control group, the PLI, GI, and SBI scores of the treatment group were decreased more significantly after treatment (P < 0.05). After treatment, the levels of IL-1β, TNF-α, and MMP-7 in the gingival crevicular fluid in two groups were significantly reduced compared to before treatment, and the level of MUC-4 was significantly increased (P < 0.05). After treatment, the levels of IL-1β, TNF-α, MMP-7, and MUC-4 in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The synergistic treatment of Cetylpyridinium Chloride Buccal Tablets and Minocycline Hydrochloride Ointment has significant therapeutic effects, which can reduce inflammatory damage and effectively improve periodontal health.

R988.2

河北省医学科学研究重点课题计划项目（20211829）