目的 探讨金莲花口服液联合盐酸米诺环素软膏治疗慢性牙周炎的临床疗效。方法 将2023年6月—2025年5月在河北医科大学口腔医院就诊的82例慢性牙周炎患者纳入研究，所有患者按随机数字表法分为对照组和治疗组，每组41例。对照组将盐酸米诺环素软膏注满患牙牙周，1次/周。治疗组在对照组基础上口服金莲花口服液，3次/d，1支/次。两组患者持续治疗4周。比较两组的临床疗效、生活质量、牙周指标、龈沟液炎症因子。结果 对照组的总有效率为80.49%，治疗组的总有效率为95.12%，组间比较差异显著（P＜0.05）。两组治疗后的口腔健康影响程度量表（OHIP-49）评分均减小（P＜0.05），且治疗后治疗组OHIP-49评分低于对照组（P＜0.05）。治疗后，两组的菌斑指数（PI）、软垢指数（DI）、牙石指数（CI）评分均减小（P＜0.05）；治疗组PI、DI、CI评分均小于对照组（P＜0.05）。两组患者治疗后的龈沟液核因子NF-κB受体活化因子配体（RANKL）/骨保护素（OPG）、基质金属蛋白酶-8（MMP-8）、高迁移率族蛋白B1（HMGB1）水平明显降低（P＜0.05），治疗组治疗后龈沟液RANKL/OPG、MMP-8、HMGB1水平低于对照组（P＜0.05）。结论 慢性牙周炎患者经金莲花口服液联合盐酸米诺环素软膏治疗，可提高患者的临床疗效、生活质量，改善牙周情况，其机制与减轻炎症反应有关。

Objective To explore the efficacy of Jinlianhua Oral Liquid combined with Minocycline Hydrochloride Ointments in treatment of chronic periodontitis. Methods 82 Patients with chronic periodontitis who visited Hospital of Stomatology Hebei Medical University from June 2023 to May 2025 were included in the study. All patients were divided into control group and treatment group using a random number table method, with 41 patients in each group. The control group filled the affected teeth with Minocycline Hydrochloride Ointments once weekly. The treatment group took Jinlianhua oral liquid orally on the basis of the control group, 3 times daily, 1 bottle per time. Two groups of patients were treated continuously for 4 weeks. The clinical efficacy, quality of life, periodontal indicators, and gingival crevicular fluid inflammatory factors were compared between two groups. Results The total effective rate of the control group was 80.49%, while the total effective rate of the treatment group was 95.12%, and the difference between two groups was significant (P < 0.05). The Oral Health Impact Scale (OHIP-49) scores were decreased in two groups after treatment (P < 0.05), and the OHIP-49 score in the treatment group was lower than that in the control group after treatment (P < 0.05). After treatment, the plaque index (PI), plaque index (DI), and calculus index (CI) scores of two groups were significantly reduced (P < 0.05), and the PI, DI, and CI scores of the treatment group were all lower than those of the control group (P < 0.05). After treatment, the levels of nuclear factor NF-κB receptor activator ligand (RANKL)/osteoprotegerin (OPG), matrix metalloproteinase-8 (MMP-8), and high mobility group protein B1 (HMGB1) in gingival crevicular fluid of two groups of patients were significantly reduced (P < 0.05), and the levels of RANKL/OPG, MMP-8, and HMGB1 in gingival crevicular fluid of the treatment group were lower than those of the control group after treatment (P < 0.05). Conclusion The combination of Jinlianhua Oral Liquid and Minocycline Hydrochloride Ointments can improve clinical efficacy in treatment of chronic periodontitis, improve quality of life, and periodontal condition, and its mechanism is related to reducing inflammatory response

R988.2

河北省重点研发计划自筹项目（172777138）