目的 探究慈航胶囊联合米索前列醇治疗气虚血瘀型产后恶露不绝的临床疗效。方法 纳入2023年2月—2025年2月就诊于唐山市中医医院的气虚血瘀型产后恶露不绝患者92例，依据治疗方案差异分为对照组（46例）和治疗组（46例）。对照组患者给予米索前列醇片，0.2 mg米索前列醇片推至直肠内距肛门约3 cm处，1次/d；治疗组在对照组基础上口服慈航胶囊，1.5 g/次，2次/d。两组均实施7 d的治疗。观察两组患者临床疗效，比较治疗前后两组患者临床症状改善时间，子宫机能指标子宫三径之和、子宫动脉阻力指数（RI）和搏动指数（PI）水平，血清纤维蛋白原（Fib）、基质金属蛋白酶-9（MMP-9）、D-二聚体（D-D）水平。结果 治疗后，对照组和治疗组总有效率分别为69.56%、89.13%，两组比较差异具有统计学意义（P＜0.05）。治疗后，治疗组恶露淋漓、腰腹坠痛、气促乏力改善时间明显短于对照组（P＜0.05）。治疗后，两组受试者子宫三径之和、子宫动脉PI和RI水平，及血清Fib、MMP-9及D-D水平均比治疗前明显下降（P＜0.05），且治疗组指标改善显著优于对照组（P＜0.05）。结论 慈航胶囊联合米索前列醇治疗气虚血瘀型产后恶露不绝具有协同增效作用，同时还可改善患者临床症状和子宫机能，同步促进血清标志物水平复常。

Objective To evaluate the clinical efficacy of Cihang Capsules combined with misoprostol in treatment of postpartum lochiorrhea with qi deficiency and blood stasis. Methods Patients (92 cases) with qi deficiency and blood stasis in Tangshan Traditional Chinese Medicine Hospital from February 2023 to February 2025 were divided into control (46 cases) and treatment (46 cases) group based on differences treatment. Patients in control group were administered with Misoprostol Tablets, 0.2 mg Misoprostol Tablets was pushed into the rectum about 3 cm away from the anus, once daily. Patients in treatment group were po administered with Cihang Capsules on the basis of the control group, 1.5 g/times, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, and the improvement time of clinical symptoms, the sum of the three diameters of the uterus, the RI and PI of uterine artery, and the levels of serum Fib, MMP-9 and D-D in two groups before and after treatment were compared. Results After treatment, the total effective rates in the control group and the treatment group were 69.56% and 89.13%, respectively, and the difference between the two groups was statistically significant (P < 0.05). After treatment, the improvement time for symptoms such as lochia, waist and abdominal pain, shortness of breath and fatigue in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the sum of three uterine diameters, uterine artery PI and RI levels, and serum Fib, MMP-9 and D-D levels in two groups were significantly lower than before treatment (P < 0.05), and the improvement of these indicators in the treatment group was significantly better than that in the control group (P < 0.05). Conclusion The combination of Cihang Capsules and misoprostol has a synergistic effect in the treatment of postpartum lochia with qi deficiency and blood stasis type. It can also improve the clinical symptoms and uterine function of patients, and promote the normalization of serum marker levels.

R984

河北省中医药科研计划项目（2021395）