目的 探讨冰黄肤乐软膏联合他克莫司软膏治疗肛周湿疹的临床疗效。方法 选取湖南中医药大学第二附属医院在2023年9月—2025年3月收治的肛周湿疹患者98例，按随机数字表法将患者分为对照组和治疗组，各组49例。对照组患者每日早晚涂抹他克莫司软膏1次，1 FTU/次。治疗组在对照组基础上涂抹冰黄肤乐软膏，3次/d，1 FTU/次，完成后按摩皮肤以促进吸收。两组患者共持续治疗4周。对比两组患者的治疗效果、症状程度、肛周皮损面积、生活质量、血清指标。结果 治疗组总有效率为93.88%，对照组的总有效率为79.59%，组间比较差异明显（P＜0.05）。治疗后，两组的瘙痒程度评分、持续时间、发作频率明显降低（P＜0.05），且治疗组的瘙痒程度评分、持续时间、发作频率低于对照组（P＜0.05）。治疗后，两组患者的肛周皮损面积、皮肤生活质量指数（DLQI）评分均降低（P＜0.05），且治疗组的肛周皮损面积、DLQI评分低于对照组（P＜0.05）。治疗后，两组的血清白三烯B4（LTB4）、白细胞介素（IL）-23、IL-12p40水平均降低（P＜0.05），治疗组的血清LTB4、IL-23、IL-12p40水平低于对照组（P＜0.05）。结论 冰黄肤乐软膏联合他克莫司软膏可提高肛周湿疹的治疗效果，减轻瘙痒症状，改善生活质量，降低炎症反应。

Objective To explore the clinical efficacy of Binghuang Fule ointment combined with Tacrolimus Ointments in treatment of perianal eczema. Methods 98 Patients with perianal eczema admitted to the Second Affiliated Hospital of Hunan University of Chinese Medicine from September 2023 to March 2025 were selected and divided into control and treatment group using a random number table method, with 49 cases per group. Patients in the control group applied Tacrolimus Ointments in the morning and evening, once daily, at a dose of 1 FTU per application. On the basis of the control group, patients in the treatment group applied Binghuang Fule Ointments, 3 times daily, 1 FTU/time, and massaged the skin after completion to promote absorption. Patients received continuous treatment for 4 weeks. The treatment efficacy, symptom severity, perianal skin lesion area, quality of life, and serum indicators between two groups of the two groups were compared. Results The total effective rate of the treatment group was 93.88%, while the total effective rate of the control group was 79.59%, and there was a significant difference between the groups (P < 0.05). After treatment, the itch severity score, duration, and frequency in both groups were significantly reduced (P < 0.05), and the itch severity score, duration, and frequency of attacks in the treatment group were lower than those in the control group (P < 0.05). After treatment, the perianal skin lesion area and DLQI score of both groups of patients were decreased (P < 0.05), and the perianal skin lesion area and DLQI score of the treatment group were lower than those of the control group (P < 0.05). After treatment, the serum levels of LTB4, IL-23, and IL-12p40 in both groups were decreased (P < 0.05), and the serum levels of LTB4, IL-23, and IL-12p40 in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Binghuang Fule Ointments and Tacrolimus Ointments can improve the therapeutic effect of perianal eczema, further alleviate itching symptoms, improve quality of life, reduce inflammatory reactions.

R976

湖南省卫生健康委科研计划项目（D202214017139）