目的 探讨康复新液联合艾普拉唑钠治疗消化性溃疡出血的临床疗效。方法 2021年3月—2024年3月选取资阳市精神病医院和资阳市中医医院收治的92例消化性溃疡出血患者参与研究，以随机数字表法分为对照组和治疗组，各46例。对照组静脉滴注注射用艾普拉唑钠，1次/d，首次剂量20 mg，后续剂量10 mg，以10 mg∶100 mL的比例与生理盐水混合使用。治疗组在对照组治疗基础上口服康复新液，10 mL/次，3次/d。两组患者疗程7 d。评估两组临床疗效，比较两组禁食时间和症状缓解时间。比较治疗前后两组Rockall、简式抑郁–焦虑–压力量表（DASS-21）和睡眠状况自评量表（SRSS）评分，及红细胞计数（RBC）、血红蛋白（Hb）、血细胞比容（HCT）、单核细胞趋化蛋白1（MCP-1）和白细胞介素-17（IL-17）水平。结果 治疗后，治疗组总有效率明显高于对照组（95.65% vs 82.61%，P＜0.05）。治疗后，治疗组患者禁食时间和各项症状缓解时间均明显短于对照组（P＜0.05）。治疗后，两组Rockall、DASS-21和SRSS评分均明显低于同组治疗前（P＜0.05），且治疗组患者明显低于对照组（P＜0.05）。治疗后，两组RBC、Hb、HCT均高于组内治疗前，而MCP-1、IL-17水平均低于同组治疗前（P＜0.05），且治疗组RBC、Hb、HCT和血清MCP-1、IL-17水平改善明显优于对照组（P＜0.05）。结论 康复新液联合艾普拉唑钠进行消化性溃疡出血的临床治疗，可显著减轻患者临床症状及体内炎症反应，消化性溃疡出血，促进胃肠道黏膜修复及出血控制，并能有效改善患者的不良情绪、睡眠及贫血状况。

Objective To explore the clinical efficacy of Kangfuxin Liquid combined with ilaprazole sodium in treatment of peptic ulcer bleeding. Methods Patients (92 cases) with peptic ulcer bleeding in Ziyang Traditional Chinese Medicine Hospital from March 2021 to March 2024 were randomly divided into control and treatment group, and each group had 46 cases. Patients in the control group were iv administered with Ilaprazole Sodium for injection, the first dose was 20 mg and subsequent dose was 10 mg, mixed with 0.9% sodium chloride solution at a ratio of 10 mg∶100 mL, once daily. Patients in the treatment group were po administered with Kangfuxin Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, and the fasting time and symptom relief time, the scores of Rockall, DASS-21 and SRSS, the levels of BC, Hb, HCT, MCP-1 and IL-17 in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was significantly higher than that in the control group (95.65% vs 82.61%, P < 0.05). After treatment, the fasting time and the relief time of various symptoms in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the scores of Rockall, DASS-21 and SRSS in two groups were significantly lower than those in the same group before treatment (P < 0.05), and patients in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, RBC, Hb, and HCT in two groups were higher than before treatment, while MCP-1 and IL-17 levels were lower than before treatment in the same group (P < 0.05). After treatment, the RBC, Hb, HCT and serum MCP-1 and IL-17 levels in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The treatment of peptic ulcer bleeding with Kangfuxin Liquid combined with ilaprazole sodium can effectively reduce gastrointestinal inflammation and clinical symptoms, promote gastrointestinal mucosal repair and bleeding control, and effectively improve patients' negative emotions, sleep, and anemia.

R975

资阳市科学技术局计划项目（KY2023086）