目的 探究血塞通软胶囊联合阿司匹林治疗老年冠心病的临床疗效。方法 选取2021年4月—2022年4月来北京中医药大学东直门医院进行治疗的106例老年冠心病患者，按照信封抽签法将所有患者分为对照组和治疗组，每组各53例。对照组口服阿司匹林肠溶片，100 mg/次，1次/d。治疗组在对照组的基础上加用血塞通软胶囊，2粒/次，2次/d。两组患者均连续治疗8周。观察两组的临床疗效，比较两组心功能指标、细胞炎性因子水平、血脂水平和生活质量调查表（SF-36）评分。结果 治疗后，治疗组总有效率是94.34%，显著高于对照组的77.36%（P＜0.05）。治疗后，两组心排血量（CO）、每搏量（SV）、左室射血分数（LVEF）均显著升高，而左室舒张末内径（LVDD）均降低（P＜0.05）；治疗后，治疗组患者心功能指标改善较对照组更明显（P＜0.05）。治疗后，两组超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）及白细胞介素-6（IL-6）水平均较同组治疗前显著下降（P＜0.05）；且治疗后，治疗组细胞炎性因子水平低于对照组（P＜0.05）。治疗后，两组高密度脂蛋白胆固醇（HDL-C）水平较同组治疗前显著升高，而总胆固醇（TC）、三酰甘油（TG）及低密度脂蛋白胆固醇（LDL-C）水平均下降（P＜0.05）；且治疗后，治疗组血脂水平改善均优于对照组（P＜0.05）。结论 血塞通软胶囊联合阿司匹林能够有效改善老年冠心病患者的临床症状，降低细胞炎性因子水平，调节血脂，提高生活质量。

Objective To investigate the therapeutic effect of Xuesaitong Soft Capsules combined with aspirin in treatment of elderly coronary heart disease. Methods A total of 106 elderly patients with coronary heart disease who were treated in Dongzhimen Hospital of Beijing University of Chinese Medicine from April 2021 to April 2022 were selected and divided into control group and treatment group according to envelope drawing method, with 53 cases in each group. Patients in control group were po administered with Aspirin Enteric-coated Tablets, 100 mg/time, once daily. Patients in treatment group were po administered with Xuesaitong Soft Capsules on the basis of control group, 2 capsules/time, twice daily. Both groups were treated continuously for 8 weeks. The clinical efficacy of two groups was observed, and the cardiac function indexes, the level of cytokines, blood lipids and score of life quality questionnaire (SF-36) were compared between two groups. Results After treatment, the total effective rate of treatment group was 94.34%, which was significantly higher than that of control group (77.36%, P < 0.05). After treatment, cardiac output (CO), stroke volume (SV) and left ventricular ejection fraction (LVEF) were significantly increased in both groups, but left ventricular end-diastolic diameter (LVDD) was decreased (P < 0.05). After treatment, the improvement of cardiac function indexes in treatment group was more obvious than that in control group (P < 0.05). After treatment, the levels of hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α)

and interleukin-6 (IL-6) in two groups were significantly decreased compared with those before treatment (P < 0.05). After treatment, the level of inflammatory cytokines in treatment group was lower than that in control group (P < 0.05). After treatment, the levels of high density lipoprotein cholesterol (HDL-C) in two groups were significantly higher than before treatment, but the levels of TC, TG and LDL-C were decreased (P < 0.05). After treatment, the improvement of blood lipid level in treatment group was better than that in control group (P < 0.05). Conclusion Xuesaitong Soft Capsules combined with aspirin in treatment of elderly coronary heart disease can effectively improve the clinical symptoms of elderly patients with coronary heart disease, and can reduce the level of inflammatory cytokines, regulate blood lipids, which can improve the quality of life.

R972

中华中医药学会委托课题（2021XS-001-06）