脑缺血再灌注损伤与氧化应激过度、炎症反应活化、神经细胞凋亡、血脑屏障受损等机制有关，临床治疗仍以溶栓、抗血小板和神经保护药物为主。枸杞多糖是枸杞中主要活性成分，具有显著的药理作用，可通过抑制神经细胞凋亡、减轻氧化应激反应、减轻炎症反应、促进神经元存活、改善线粒体功能、保护血脑屏障结构和功能减轻脑缺血再灌注损伤。总结了枸杞多糖治疗脑缺血再灌注损伤的药理作用研究进展，为枸杞多糖的临床应用提供参考。

Cerebral ischemia-reperfusion injury is associated with mechanisms such as excessive oxidative stress, activation of inflammatory responses, neuronal apoptosis, and damage to the blood-brain barrier. Clinical treatment primarily focuses on thrombolytic agents, antiplatelet drugs, and neuroprotective medications. Lycium barbarum polysaccharides are the main active ingredients in Lycium barbarum and have significant pharmacological effects. Lycium barbarum polysaccharides can alleviate cerebral ischemia-reperfusion injury by inhibiting neuronal apoptosis, reducing oxidative stress response, alleviating inflammatory response, promoting neuronal survival, improving mitochondrial function, and protecting blood-brain barrier structure and function. This article summarizes the pharmacological research progress of Lycium barbarum polysaccharides in treating cerebral ischemia-reperfusion injury, providing reference for the clinical application of Lycium barbarum polysaccharides.

R971

青岛市医药科研指导计划（2020-WJZD121）