多囊卵巢综合征是育龄女性常见的内分泌和代谢异常疾病，病理机制复杂，治疗难度较大。小檗碱可通过减轻胰岛素抵抗、减轻炎症反应、减轻氧化应激损伤、抑制颗粒细胞死亡、调节肠道菌群、调节糖脂代谢、调节性激素分泌、改善卵丘扩展、抑制血管过度生成、抑制子宫异常增生发挥治疗多囊卵巢综合征的作用。总结了小檗碱防治多囊卵巢综合征的药理作用研究进展，为小檗碱的临床运用提供依据。

Polycystic ovary syndrome is a common endocrine and metabolic disorder among women of reproductive age, characterized by complex pathological mechanisms and significant treatment challenges. Berberine can exert therapeutic effects on polycystic ovary syndrome by alleviating insulin resistance, reducing inflammation, mitigating oxidative stress damage, inhibiting granulosa cell death, modulating intestinal microbiota, regulating glucose and lipid metabolism, controlling sex hormone secretion, improving cumulus expansion, suppressing excessive angiogenesis, and inhibiting abnormal uterine hyperplasia. This article summarizes the pharmacological research progress on pharmacological effects of berberine in prevention and treatment of polycystic ovary syndrome, providing a basis for its clinical application.

R984

河北省中医药管理局科研计划项目（2021454）