抗精神病药物是治疗精神分裂症的主要方法，但抗精神病药物所致代谢综合征是医生和患者面临的首要问题。抗精神病药物所致代谢综合征的临床表现有葡萄糖代谢紊乱、血脂异常、体质量异常和泌乳素水平异常，目前临床主要以对症治疗为主，通过降低原有抗精神病药物剂量、选择适合的抗精神病药物、联合用药进行药物干预。总结了抗精神病药物所致代谢综合征的临床表现、发生机制和药物干预策略，以期为临床、社区精神分裂症的治疗提供帮助。

Antipsychotic drugs are the main method in treatment of schizophrenia, but metabolic syndrome induced by antipsychotic drugs is the primary issue faced by doctors and patients. The clinical manifestations of metabolic syndrome induced by antipsychotic drugs include glucose metabolism disorders, abnormal blood lipids, abnormal body mass, and abnormal prolactin levels. Currently, symptomatic treatment is mainly used in clinical practice, which involves reducing the dosage of existing antipsychotic drugs, selecting suitable antipsychotic drugs, and using combination therapy for drug intervention. This article summarizes the clinical manifestations, mechanisms of action, and drug intervention strategies of metabolic syndrome induced by antipsychotic drugs, in order to provide assistance for the treatment of schizophrenia in clinical and community settings.

R971

宁夏回族自治区重点研发计划项目（2024BEG02026）