溃疡性结肠炎是一种复杂的免疫介导的慢性炎症性病变，主要影响结肠部位。鞣花酸是一种天然多酚化合物，可通过降低炎症损伤、抗氧化应激、修复肠道屏障功能、调节肠道菌群平衡、免疫调节发挥其治疗溃疡性结肠炎的作用。总结了鞣花酸治疗溃疡性结肠炎的药理作用研究进展，为鞣花酸的临床应用提供支持。

Ulcerative colitis is a complex immune-mediated chronic inflammatory condition primarily affecting the colon. Ellagic acid is a natural polyphenolic compound that exerts its therapeutic effects on ulcerative colitis by reducing inflammatory damage, anti-oxidative stress, repairing intestinal barrier function, modulating gut microbiota balance, and regulating immunity. This article summarizes the research progress on the pharmacological effects of ellagic acid in treatment of ulcerative colitis, providing support for the clinical application of ellagic acid.

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黑龙江省自然科学基金联合引导项目（LH2022H068）；中国博士后科学基金资助课题（2015M581496）；黑龙江省卫生健康委科研课题立项（20220202080996）；黑龙江省中医药科研课题项目（ZHY2025-180）；黑龙江中医药大学研究生创新科研项目立项基金（2022yjscx012， 2019yjscx011）