目的 观察金喉健喷雾剂联合西地碘含片对复发性口腔溃疡患者临床疗效及血清因子的影响。方法 研究对象均选自2024年1月—2024年12月开滦总医院收治的100例复发性口腔溃疡患者，依据组间匹配原则将患者分为对照组和治疗组，每组各50例。对照组口含西地碘含片，1片/次，3次/d。治疗组在对照组治疗方案结束间隔几分钟后喷洒金喉健喷雾剂，喷洒在溃疡表面，5次/d，2～3喷/次。两组患者均连续治疗2周。观察两组的临床疗效，比较两组血清因子水平、疼痛程度及平均溃疡期。结果 治疗后，治疗组总有效率是96.00%，显著高于对照组的82.00%（P＜0.05）。治疗后，两组C反应蛋白（CRP）、白细胞介素-2（IL-2）、肿瘤坏死因子-α（TNF-α）水平均较治疗前下降（P＜0.05），且治疗组CRP、IL-2、TNF-α水平显著低于对照组（P＜0.05）。治疗后，两组视觉模拟评分法（VAS）评分较治疗前显著下降（P＜0.05），且治疗后治疗组VAS评分显著低于对照组，治疗组平均溃疡期较对照组短（P＜0.05）。结论 金喉健喷雾剂联合西地碘含片治疗复发性口腔溃疡患者可有效提高临床治疗效果，改善患者溃疡期疼痛程度，缩短溃疡发作时间，纠正异常血清因子水平，且不会额外增加患者不良反应。

Objective To observe the clinical efficacy and serum factor influence of Jinhoujian Spray combined with Cydiodine Buccal Tablets on patients with recurrent oral ulcers. Methods The research subjects were all selected from 100 patients with recurrent oral ulcers admitted to Kailuan General Hospital from January 2024 to December 2024. According to the principle of matching between groups, the patients were divided into the control group and the treatment group, with 50 cases in each group. Patients in control group held Cydiodine Buccal Tablets in their mouths, 1 tablet each time, 3 times daily. Patients in treatment group sprayed Jinhoujian Spray on the ulcer surface a few minutes after the end of the treatment plan of the control group, 5 times daily, 2 to 3 times each time. Both groups of patients were treated continuously for 2 weeks. The clinical efficacy of two groups was observed, and the serum factor levels, pain degrees and average ulcer periods of two groups were compared. Results After treatment, the total effective rate of the treatment group was 96.00%, significantly higher than that of the control group (82.00%, P < 0.05). After treatment, the levels of CRP, IL-2, and TNF-α in both groups decreased compared with those before treatment (P < 0.05), and the levels of CRP, IL-2, and TNF-α in treatment group were significantly lower than those in control group (P < 0.05). After treatment, the VAS scores of both groups decreased significantly compared with those before treatment (P < 0.05), and the VAS score of treatment group was significantly lower than that of control group after treatment. The average ulcer period of treatment group was shorter than that of control group (P < 0.05). Conclusion The combination of Jinhoujian spray and Cydiodine Buccal Tablets in treatment of patients with recurrent oral ulcers with can effectively improve the clinical therapeutic effect, alleviate the pain degree during the ulcer period, shorten the ulcer attack time, correct the abnormal serum factor levels, and will not increase the adverse reactions of patients.

R988.2

河北省医学科学研究重点课题计划项目（20231858）