目的 探讨骨通贴膏与双醋瑞因联合治疗膝关节骨性关节炎患者的临床疗效。方法 采集2022年1月—2024年12月在华北医疗健康集团峰峰总医院治疗的100例膝关节骨性关节炎患者病例资料进行回顾性分析。依据治疗方案差异分为对照组和治疗组，每组各50例。对照组口服双醋瑞因胶囊，1粒/次，2次/d。治疗组在对照组基础上联合骨通贴膏贴敷。两组患者治疗1个月。观察两组患者临床疗效，比较治疗前后两组患者疼痛程度、骨关节炎指数（WOMAC）、膝关节损伤和骨关节炎结局评分（KOOS量表）评分，血清白细胞介素-1（IL-1）、IL-1β、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）表达水平，及临床症状缓解时间。结果 治疗后，治疗组总有效率高于对照组（94.00% vs 80.00%，P＜0.05）。治疗后，两组视觉模拟评分法（VAS）、WOMAC明显低于治疗前，而KOOS量表评分明显升高（P＜0.05），且治疗后治疗组评分较对照组显著下降，KOOS评分显著升高（P＜0.05）。治疗后，两组血清IL-1、IL-1β、CRP、TNF-α表达水平明显低于治疗前（P＜0.05），而治疗组IL-1、IL-1β、CRP、TNF-α表达较对照组更低（P＜0.05）。治疗后，治疗组关节肿胀、关节疼痛及关节活动受限缓解时间均较对照组早（P＜0.05）。结论 双醋瑞因胶囊与骨通贴膏联合治疗膝关节骨性关节炎可显著提升临床疗效，有效改善关节炎症反应，促进膝关节功能康复，加速临床不适症状缓解，同时具有良好的用药安全性。

Objective To investigate the clinical efficacy of Gutong Plaster combined with diacerein in treatment of knee osteoarthritis. Methods The clinical data of patients (100 cases) with knee osteoarthritis in Fengfeng General Hospital of North China Healthcare Group from January 2022 to December 2024 were analyzed retrospectively. They were divided into control and treatment group based on different treatments, and each group had 50 cases. Patients in the control group were po administered with Diacerein Capsules, 1 grain/time, twice daily. Patients in the treatment group were administered with Gutong Plaster on the basis of the control group. Patients in two groups were treated for 1 month. After treatment, the clinical evaluations were evaluated, and the pain severity, WOMAC, and KOOS scores, serum biochemical indexes IL-1, IL-1β, CRP, and TNF-α levels, and the clinical symptom relief time in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was higher than that in the control group (94.00% vs 80.00%, P < 0.05). After treatment, the VAS and WOMAC in two groups were significantly lower than before treatment, while the KOOS scale score was significantly increased (P < 0.05). After treatment, the score in the treatment group was significantly decreased compared with the control group, and the KOOS score was significantly increased (P < 0.05). After treatment, the expression levels of serum IL-1, IL-1β, CRP, and TNF-α in two groups were significantly lower than those before treatment (P < 0.05), while the expression levels in the treatment group were lower than those in the control group (P < 0.05). After treatment, the relief time of joint swelling, joint pain and joint motion limitation in the treatment group was earlier than that in the control group (P < 0.05). Conclusion For knee osteoarthritis patients, the combined treatment of diacerein capsules and Gutong Plaster significantly enhances clinical efficacy, effectively alleviates joint inflammation, promotes knee joint functional recovery, accelerates symptom relief, and demonstrates favorable safety profiles.

R977

河北省医学科学研究课题计划项目（20220421）