目的 探讨宫炎平片联合甲硝唑呋喃唑酮栓治疗慢性宫颈炎的临床疗效。方法 选取2022年1月—2025年6月深圳市龙华区中心医院收治的94例慢性宫颈炎患者，将患者按随机数字表法分为对照组和治疗组，各47例。对照组隔日睡前阴道给药甲硝唑呋喃唑酮栓，1枚/次。治疗组在对照组基础上口服宫炎平片，4片/次，3次/d。两组患者持续治疗30 d。比较两组患者治疗效果、生活质量、症状消失时间、血清指标。结果 治疗组的治愈率为93.62%，对照组的治愈率为78.72%，组间比较差异显著（P＜0.05）。治疗后，两组患者GQOLI-74评分显著升高（P＜0.05），且治疗组的GQOLI-74评分高于对照组（P＜0.05）。治疗组患者白带增多、外阴瘙痒、下腹酸痛、不规则出血消失时间均短于对照组（P＜0.05）。治疗后，两组患者的血清白细胞介素-4（IL-4）、肿瘤坏死因子-α（TNF-α）、血清淀粉样蛋白A（SAA）水平显著降低（P＜0.05），且治疗组的血清IL-4、TNF-α、SAA水平低于对照组（P＜0.05）。结论 宫炎平片联合甲硝唑呋喃唑酮栓可提高慢性宫颈炎的临床疗效，改善临床症状，提高生活质量，减轻炎症反应。

Objective To investigate the clinical efficacy of Gongyanping Tablets combined with Metronidazole and Furazolidone Suppositories in treatment of chronic cervicitis. Methods A total of 94 patients with chronic cervicitis admitted to Shenzhen Longhua District Central Hospital from January 2022 to June 2025 were selected. The patients were divided into control group and treatment group according to the random number table method, with 47 cases in each group. Patients in the control group received vaginal administration of Metronidazole and Furazolidone Suppositories every other day before bedtime, with one suppository per time. The treatment group additionally took Gonyanping Tablets orally on the base of the control group regimen at a dosage of four tablets per time, three times daily. Two groups received continuous treatment for 30 d. The therapeutic efficacy, quality of life, symptom disappearance time, and serum indicators were compared between two groups. Results The cure rate in the treatment group was 93.62%, while that in the control group was 78.72%, with a significant difference between two groups (P < 0.05). After treatment, the GQOLI-74 scores of two groups significantly increased (P < 0.05), and the GQOLI-74 score in the treatment group was higher than that in the control group (P < 0.05). The disappearance times of increased vaginal discharge, vulvar itching, lower abdominal pain, and irregular bleeding was shorter than those in the treatment group (P < 0.05). After treatment, the serum levels of interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α), and serum amyloid A (SAA) significantly decreased in two groups (P < 0.05), and levels of serum IL-4, TNF-α, and SAA in the treatment group were lower thanthose in the control group (P < 0.05). Conclusion The combination of Gongyanping Tablets and Metronidazole and Furazolidone Suppositories can improve the clinical efficacy of chronic cervicitis, alleviate clinical symptoms, enhance quality of life, and reduce inflammatory reactions.

R984

深圳市龙华区医疗卫生机构区级科研项目（2021151）