目的 探讨产复康颗粒联合米索前列醇片治疗产后出血的临床疗效。方法 选取2023年1月—2024年12月在南京市浦口人民医院就诊的86例产后出血患者，按随机数字表法将所有患者分为对照组和治疗组，每组各43例。对照组患者口服米索前列醇片，3片/次，1次/d。治疗组在对照组基础上口服产复康颗粒，2袋/次，3次/d。两组持续治疗2周。比较两组患者的临床疗效、症状体征恢复情况、凝血功能指标、血清指标。结果 对照组的治愈率为83.72%，治疗组的治愈率为95.35%，组间比较差异有统计学意义（P＜0.05）。治疗组患者用药后24 h流血量、止血时间、恶露排净时间均低于对照组（P＜0.05）。治疗后两组的纤维蛋白原（FIB）、活化部分凝血活酶时间（APTT）、D-二聚体显著降低（P＜0.05），治疗组的FIB、APTT、D-二聚体低于对照组（P＜0.05）。治疗后两组的血清脑利钠肽（BNP）、血管性血友病因子（vWF）、凝血酶敏感蛋白-2（TSP-2）水平降低（P＜0.05），治疗组的血清BNP、vWF、TSP-2水平低于对照组（P＜0.05）。结论 产复康颗粒联合米索前列醇片可提高产后出血的临床疗效，提高止血效果和促进子宫恢复，改善凝血功能，机制与改善血管内皮功能和血小板功能有关。

Objective To investigate the clinical efficacy of Chanfukang Granules combined with Misoprostol Tablets in treatment of postpartum hemorrhage. Methods Eighty-six patients with postpartum hemorrhage who received treatment at Nanjing Pukou People’s Hospital from January 2023 to December 2024 were selected and divided into control group and treatment group using a random number table method, with 43 patients in each group. The control group took Misoprostol Tablets orally, three tablets/time, once daily. The treatment group took Chanfukang Granules orally on the basis of the control group, 2 bags/time, three times daily. Two groups continued treatment for two weeks. The clinical efficacy, recovery of symptoms and signs, coagulation function indicators, and serum indicators were compared between two groups of patients. Results The cure rate of the control group was 83.72%, while the cure rate of the treatment group was 95.35%, and the difference between the groups was statistically significant (P < 0.05). The bleeding volume 24 h after medication, hemostasis time, and complete lochia discharge time in the treatment group were lower than those in the control group (P < 0.05). After treatment, fibrinogen (FIB), activated partial thromboplastin time (APTT), and D-dimer in two groups were significantly reduced (P < 0.05). FIB, APTT, and D-dimer in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of brain natriuretic peptide (BNP), von Willebrand factor (vWF), and thrombomodulin-2 (TSP-2) in two groups decreased (P < 0.05), and the serum levels of BNP, vWF, and TSP-2 in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Chanfukang Granules and Misoprostol Tablets can improve the clinical efficacy of postpartum hemorrhage, enhance hemostasis and promote uterine recovery, improve coagulation function, and the mechanism is related to the improvement of vascular endothelial function and platelet function.

R984

江苏省妇幼健康科研项目（F201702）