阿尔茨海默病是全球范围内最常见的神经退行性疾病，主要出现在老年群体中，其核心特征为认知功能出现障碍，同时伴随记忆功能的紊乱。丹参酮Ⅱ_A是丹参中的脂溶性成分，可通过抑制β-淀粉样蛋白的生成和促进清除、调节Tau蛋白磷酸化、减轻神经炎症、改善氧化应激、调节胆碱能系统、抑制内质网应激来治疗阿尔茨海默病。总结了丹参酮Ⅱ_A治疗阿尔茨海默病的药理作用研究进展，为丹参酮Ⅱ_A治疗阿尔茨海默病的临床应用提供支持。

Alzheimer's disease is the most common neurodegenerative disorder worldwide, primarily affecting the elderly population. Its core features include cognitive dysfunction and accompanying memory impairment. Tanshinone II_A, a lipid-soluble component from Salviae Miltiorrhizae Radix, can treat Alzheimer's disease by inhibiting the production and promoting the clearance of β-amyloid protein, regulating Tau protein phosphorylation, alleviating neuroinflammation, improving oxidative stress, modulating the cholinergic system, and suppressing endoplasmic reticulum stress. This article summarizes the pharmacological research progress of tanshinone II_A in treatment of Alzheimer's disease, providing support for its clinical application.

R285;R971

中国博士后科学基金资助项目（2015M581496）；黑龙江省自然科学基金联合引导项目（LH2022H068）；黑龙江省卫生健康委科研项目（20220202080996）；黑龙江中医药大学研究生创新科研项目（2022yjscx012，2019yjscx011，2024yjsc027）；中医药科研课题（ZHY2025-180）