目的 探讨冰硼散与西帕依固龈液联合治疗急性放射性口腔黏膜炎的临床疗效。方法 回顾性选取2023年3月—2025年3月湖北省中医院口腔科收治的急性放射性口腔黏膜炎患者78例，根据用药差异分为对照组和治疗组，每组各39例。对照组患者含漱西帕依固龈液，3～5 mL/次，2～3 min/次，3～5次/d。在对照组基础上，治疗组敷以冰硼散，每次少量，一日数次。两组用药28 d观察治疗情况。观察两组患者临床疗效，比较治疗前后两组患者中医症状积分，疼痛数字评分法（NRS）评分和口腔评估指南（OAG）评分，及血清血管内皮生长因子（VEGF）、缺氧诱导因子-1α（HIF-1α）、肿瘤坏死因子-α（TNF-α）和促肾上腺皮质激素（ACTH）水平。结果 治疗后，治疗组有效率高于对照组（97.44% vs 76.92%，P＜0.05）。治疗后，两组症状积分、NRS评分和OAG评分比治疗前明显降低（P＜0.05），且与对照组对比，治疗组治疗后评分更低（P＜0.05）。治疗后，两组VEGF、HIF-1α、TNF-α、ACTH水平比治疗前显著降低（P＜0.05），且治疗后治疗组血清因子水平均明显低于对照组（P＜0.05）。结论 冰硼散与西帕依固龈液协同治疗急性放射性口腔黏膜炎效果显著，可缓解口腔疼痛，能降低口腔炎性因子，改善患者口腔基本情况。

Objective To explore the clinical study of Bingpeng Powder combined with Xipayi Guyin Fluid in treatment of acute radiation-induced oral mucositis. Methods Patients (78 cases) with acute radiation-induced oral mucositis in Hubei Provincial Hospital of Traditional Chinese Medicine from March 2023 to March 2025 were retrospectively selected and randomly divided into control and treatment group, and each group had 39 cases. Patients in the control group were gargled with Xipayi Guyin Fluid, 3 — 5 mL/time, 2 — 3 min/time, 3 — 5 times daily. Patients in the treatment group were administered with Bingpeng Powder on the basis of the control group, small amount each time, several times a day. Patients in two groups were treated for 28 d. After treatment, the clinical evaluations were evaluated, and the TCM symptom scores, NRS and OAG scores, and the levels of VEGF, HIF-1α, TNF-α and ACTH in two groups before and after treatment were compared. Results After treatment, the effective rate in the treatment group was higher than that in the control group (97.44% vs. 76.92%, P < 0.05). After treatment, the symptom scores, NRS scores, and OAG scores in two groups were significantly lower than those before treatment (P < 0.05), and compared with the control group, the scores in the treatment group were decreased more significantly after treatment (P < 0.05). After treatment, the levels of VEGF, HIF-1α, TNF-α, and ACTH in two groups were significantly lower than those before treatment (P < 0.05). Compared with the control group, the serum factor levels in the treatment group were significantly lower than those in the control group after treatment (P < 0.05). Conclusion The synergistic treatment of Bingpeng Powder and Xipayi Guyin Fluid has a significant effect on acute radiation-induced oral mucositis, which can alleviate oral pain, reduce oral inflammatory factors and improve the basic oral conditions.

R988.2

湖北省中医药管理局中医药科研项目（ZY2025L256）