目的 探讨产复康颗粒联合卡前列素氨丁三醇治疗宫缩乏力性产后出血的临床疗效。方法 纳入2022年1月—2025年3月山西省儿童医院收治的100例宫缩乏力性产后出血患者，依据治疗方式的差异分为对照组和治疗组，各50例。对照组给予卡前列素氨丁三醇注射液，250 μg/次，若子宫收缩未改善则重复给药，最大剂量不可超过2 mg。治疗组在对照组基础上口服产复康颗粒，5 g/次，3次/d。两组均治疗3 d。观察两组患者临床疗效和出血相关情况，比较两组凝血相关指标和血常规指标。结果 治疗后，治疗组总有效率是98.00%，显著高于对照组的86.00%（P＜0.05）。治疗组产后2 h及产后24 h出血量均较对照组少，止血奏效时间短于对照组（P＜0.05）。两组治疗后纤维蛋白原（FIB）、凝血酶原时间（PT）及凝血酶时间（TT）均显著低于治疗前（P＜0.05），且治疗组FIB、PT与TT水平均低于对照组（P＜0.05）。两组患者治疗后红细胞计数（RBC）、红细胞比容（HCT）、血红蛋白（Hb）与治疗前比较均显著降低，差异均具有统计学意义（P＜0.05）；且治疗后治疗组RBC、HCT及Hb高于对照组，差异具有统计学意义（P＜0.05）。结论 宫缩乏力性产后出血患者给予产复康颗粒联合卡前列素氨丁三醇治疗可减少产后出血量，利于改善血常规及凝血相关指标，安全性尚可。

Objective To explore the clinical efficacy of Chanfukang Granules combined with carboprost tromethamine in treatment of postpartum hemorrhage due to uterine atony. Methods A total of 100 patients with postpartum hemorrhage due to uterine atony admitted to Shanxi Children's Hospital from January 2022 to March 2025 were included. They were divided into control group and treatment group according to differences in treatment methods, with 50 cases in each group. Patients in control group were given Carboprost Tromethamine Injection, 250 μg each time. If uterine contractions did not improve, the administration was repeated, and the maximum dose should not exceed 2 mg. Patients in treatment group were po administered with Chanfukang Granules on basis of control group, 5 g each time, three times daily. Both groups were treated for 3 d. The clinical efficacy and bleeding related conditions of two groups were observed, and the coagulation-related indicators and blood routine indicators of two groups were compared. Results

After treatment, the total effective rate of the treatment group was 98.00%, significantly higher than that of the control group (86.00%, P < 0.05). The amount of bleeding in treatment group at 2 h and 24 h after delivery was less than that in control group, and the effective hemostasis time was shorter than that in control group (P < 0.05). After treatment, fibrinogen (FIB), prothrombin time (PT), and thrombin time (TT) in both groups were significantly lower than those before treatment (P < 0.05), and the levels of FIB, PT, and TT in treatment group were all lower than those in control group (P < 0.05). After treatment, the red blood cell count (RBC), hematocrit (HCT), and hemoglobin (Hb) of both groups of patients were significantly lower than those before treatment, and the differences were statistically significant (P < 0.05). Moreover, after treatment, the RBC, HCT and Hb in treatment group were higher than those in control group, and the difference was statistically significant (P < 0.05). Conclusion For patients with postpartum hemorrhage due to uterine atony, the treatment of Chanfukang Granules combined with carboprost tromethamine can reduce the amount of postpartum hemorrhage, facilitate the improvement of blood routine and coagulation-related indicators, and the safety is acceptable.

R984

山西省基础研究计划项目（202203021211064）