目的 探讨大黄䗪虫胶囊联合达那唑栓治疗子宫内膜异位症的临床疗效。方法 选取2022年4月—2025年3月上海市嘉定区南翔医院收治的子宫内膜异位症患者共计120例，将患者按随机数字表法分为对照组和治疗组，每组60例。对照组患者阴道给予达那唑栓，1粒/次，1次/d，月经停用4 d。治疗组在对照组的基础上口服大黄䗪虫胶囊，4粒/次，2次/d。两组患者的疗程为4个月。比较两组患者的治疗效果、疼痛程度、生活质量、超声指标、血清指标。结果 对照组的总有效率为86.67%，治疗组的总有效率为96.67%，组间比较差异显著（P＜0.05）。两组治疗后的数字疼痛强度量表（NRS）评分显著降低，自我生活质量评估量表（SEQOL）评分显著升高（P＜0.05）；治疗组治疗后的NRS评分低于对照组，SEQOL评分高于对照组（P＜0.05）。两组治疗后的痛性结节直径、囊肿体积、子宫体积均降低（P＜0.05），治疗组治疗后的痛性结节直径、囊肿体积、子宫体积低于对照组（P＜0.05）。两组治疗后的血清B细胞淋巴瘤因子6（BCL6）、基质金属蛋白酶-2（MMP-2）、血管内皮细胞生长因子（VEGF）水平均显著降低（P<0.05），且治疗组治疗后血清BCL6、MMP-2、VEGF水平明显低于对照组（P＜0.05）。结论 大黄䗪虫胶囊联合达那唑栓可提高子宫内膜异位症的临床疗效，可减轻疼痛程度，提高生活质量，改善卵巢状态，抑制新生血管形成。

Objective To investigate the clinical efficacy of Dahuang Zhechong Capsules combined with Danazol Suppositories in treatment of endometriosis. Methods 120 Patients with endometriosis admitted to Shanghai Jiading Nanxiang Hospital from April 2022 to March 2025 were selected and divided into control group and treatment group using a random number table method, with 60 cases in each group. The control group patients were given Danazol Suppositories vaginally, 1 pill/time, once daily, and menstrual cessation for 4 d. The treatment group patients were given Dahuang Zhechong Capsules orally on the base of the control group, 4 pills/time, twice daily. The treatment course for two groups of patients was 4 months. The treatment efficacy, pain level, quality of life, ultrasound indicators, and serum indicators were compared between two groups of patients. Results The total effective rate of the control group was 86.67%, while the total effective rate of the treatment group was 96.67%, with significant differences between two groups (P < 0.05). After treatment, the Digital Pain Intensity Scale (NRS) scores significantly decreased in two groups, while the Self Evaluation of Quality of Life Scale (SEQOL) scores significantly increased (P < 0.05). The NRS score of the treatment group was lower than that of the control group after treatment, while the SEQOL score was higher than that of the control group (P < 0.05). After treatment, the diameter of painful nodules, cyst volume, and uterine volume in two groups decreased (P < 0.05), and the diameter of painful nodules, cyst volume, and uterine volume in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of B-cell lymphoma factor 6 (BCL6), matrix metalloproteinase-2 (MMP-2), and vascular endothelial growth factor (VEGF) in two groups were significantly reduced (P < 0.05), and the serum levels of BCL6, MMP-2, and VEGF in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion The combination of Dahuang Zhechong Capsules and Danazol Suppositories can improve the clinical efficacy of endometriosis, alleviate pain, improve quality of life, improve ovarian status, and inhibit neovascularization.

R984

上海市嘉定区卫生健康委员会科研课题（2021-KY-06）