目的 探讨消渴康颗粒联合沙格列汀治疗2型糖尿病的临床疗效。方法 选取2023年5月—2024年12月在西安医学院第二附属医院就诊的2型糖尿病患者106例，利用随机数字表分为对照组和治疗组，每组各53例。对照组患者口服沙格列汀片，5 mg/次，1次/d。治疗组患者在对照组治疗基础上，餐前口服消渴康颗粒，1袋/次，3次/d。两组患者共治疗30 d。观察两组患者临床疗效，比较治疗前后两组患者血糖指标空腹血糖（FPG）、餐后2 h血糖（2 h PG）和糖化血红蛋白（HbA1c）水平，胰岛素抵抗指标空腹胰岛素（FIns）、胰岛素抵抗指数（HOMA-IR）和胰岛β细胞功能指数（HOMA-β）值。结果 治疗后，治疗组的总有效率提升至94.34%，显著优于对照组的79.25%（P＜0.05）。治疗后，两组病患FPG、2 h PG以及HbA1c水平明显下降（P＜0.05），与对照组相比，治疗组的血糖指标显著更低（P＜0.05）。治疗后，两组FIns和HOMA-IR水平显著降低，而HOMA-β值显著上升（P＜0.05），且治疗后治疗组这些指标显著好于对照组（P＜0.05）。结论 消渴康颗粒与沙格列汀片联合治疗2型糖尿病效果显著，能有效降低血糖水平，调节血脂平衡，改善胰岛素抵抗状况。

Objective To investigate the clinical efficacy of iaokekang Granules combined with saxagliptin in treatment of type 2 diabetes. Methods Patients (106 cases) with type 2 diabetes in the Second Affiliated Hospital of Xi'an Medical University from May 2023 to December 2024 were divided into control and treatment group according to random number table method, and each group had 53 cases. Patients in the control group were po administered with Saxagliptin Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Xiaokekang Granules before meals on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 30 d. After treatment, the clinical evaluations were evaluated, and the levels of FPG, 2 h PG, HbA1c, Fins, HOMA-IR and HOMA-β in two groups before and after treatment were compared. Results After treatment, the overall effective rate in the treatment group increased to 94.34%, which was significantly better than 79.25% in the control group (P < 0.05). After treatment, the levels of FPG, 2 h PG and HbA1c in two groups were significantly decreased (P < 0.05). Compared with the control group, the blood glucose indicators in the treatment group were significantly lower (P < 0.05). After treatment, the levels of FIns and HOMA-IR in two groups were significantly decreased, while the value of HOMA-β was significantly increased (P < 0.05), and these indicators in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The combination of Xiaokekang Granules and Saxagliptin Tablets has a significant therapeutic effect on type 2 diabetes, which can lower blood glucose, regulate blood lipids, inhibit inflammatory reactions, improve insulin resistance.

R977

陕西省卫生健康科研基金资助项目（2024D062）