目的 探讨四磨汤口服液联合匹维溴铵片治疗功能性消化不良的临床疗效。方法 选取2022年7月—2025年6月广州市中西医结合医院收治80例的功能性消化不良患者，将患者按随机数字表法分为对照组和治疗组，每组各40例。对照组口服匹维溴铵片，1片/次，3次/d。治疗组在对照组基础上口服四磨汤口服液，2支/次，3次/d。两组患者持续治疗1周。比较两组患者的治疗效果、症状改善时间、胃排空时间、生活质量、血清指标。结果 治疗组的总有效率为97.50%，对照组的总有效率为85.00%，组间比较差异显著（P＜0.05）。治疗组患者上腹不适、胃烧灼感、早饱、餐后饱胀改善时间均短于对照组（P＜0.05）。两组治疗后的胃排空时间均缩短，尼平消化不良指数（NDI）评分升高（P＜0.05）；治疗组治疗后的胃排空时间短于对照组，NDI评分高于对照组（P＜0.05）。治疗后，两组的血清血管活性肠肽（VIP）水平显著降低，血清神经肽（NPY）、瘦素（LEP）水平显著升高（P＜0.05）；治疗组治疗后的血清VIP水平低于对照组，血清NPY、LEP水平高于对照组（P＜0.05）。结论 四磨汤口服液联合匹维溴铵片可提高功能性消化不良的临床疗效，改善临床症状和生活质量，促进胃排空，调节胃肠激素分泌。

Objective To investigate the clinical efficacy of Simotang Oral Liquid combined with Pinaverium Bromide Tablets in treatment of functional dyspepsia. Methods 80 Patients with functional dyspepsia admitted to Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine from July 2022 to June 2025 were selected, and divided into control group and treatment group using a random number table method, with 40 patients in each group. The control group took oral Pivium Bromide Tablets, 1 tablets/time, 3 times daily. The treatment group was po administered with Simotang Oral Liquid on the base of the control group, 2 tablets/time, 3 times daily. Two groups of patients continued treatment for 1 week. The treatment efficacy, symptom improvement time, gastric emptying time, quality of life, and serum indicators were compared between two groups of patients. Results The total effective rate of the treatment group was 97.50%, while the total effective rate of the control group was 85.00%, and the difference between two groups was significant (P < 0.05). The improvement time of upper abdominal discomfort, gastric burning sensation, early satiety, and postprandial fullness in the treatment group was shorter than that in the control group (P < 0.05). The gastric emptying time was shortened in two groups after treatment, but the Niping Digestive Dysfunction Index (NDI) score increased (P < 0.05). After treatment, the gastric emptying time of the treatment group was shorter than that of the control group, but the NDI score was higher than that of the control group (P < 0.05). After treatment, the serum levels of vasoactive intestinal peptide (VIP) significantly decreased in two groups, while the serum levels of neuropeptide (NPY) and leptin (LEP) significantly increased (P < 0.05). The serum levels of VIP in the treatment group was lower than that in the control group after treatment, while the serum levels of NPY and LEP were higher than those in the control group (P < 0.05). Conclusion The combination of Simotang Oral Liquid and Pinaverium Bromide Tablets can improve the clinical efficacy of functional dyspepsia, improve clinical symptoms and quality of life, promote gastric emptying, and regulate gastrointestinal hormone secretion.

R975

广东省中医药局科研项目（20221314）