目的 探讨小儿消食颗粒联合乳酸菌素治疗儿童功能性消化不良的临床疗效。方法 选取苏州市吴江区儿童医院2022年4月—2024年12月收治的功能性消化不良患儿124例，随机分为对照组和治疗组，每组各62例。对照组口服乳酸菌素颗粒，1 g/次，3次/d。治疗组在对照组基础上口服小儿消食颗粒，7岁1次1～1.5袋，7岁以上患儿1次1.5袋，3次/d。两组患儿均治疗4周。观察两组患儿临床疗效，比较治疗前后两组患儿症状缓解评分，炎症因子指标白细胞介素-6（IL-6）、C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α），胃肠激素指标胃泌素（GAS）、血管活性肠肽（VIP）和胃动素（MOT），胃动力学指标胃窦收缩频率、胃窦收缩幅度和胃排空率。结果 治疗后，治疗组总有效率明显高于对照组（91.94% vs 77.42%，P＜0.05）。治疗后，两组患儿症状评分明显降低（P＜0.05），且治疗组症状缓解评分包括早饱、饱胀感、上腹痛、烧灼感均低于对照组（P＜0.05）。治疗后，两组患儿IL-6、CRP、TNF-α均显著降低（P＜0.05），且治疗组患者炎症因子均低于对照组（P＜0.05）。治疗后，两组GAS、MOT明显高于治疗前，而VIP低于治疗前（P＜0.05），且治疗组胃肠激素指标明显好于对照组（P＜0.05）。治疗后，两组患儿胃窦收缩频率、胃窦收缩幅度、胃排空率高于治疗前（P＜0.05），且治疗组胃动力学指标明显高于对照组（P＜0.05）。结论 小儿消食颗粒联合乳酸菌素治疗儿童功能性消化不良的效果良好，可促进患儿症状消退，降低炎症反应，改善胃肠激素和胃动力学。

Objective To investigate the clinical effect of Xiaoer Xiaoshi Granules combined with lacidophilin in treatment of children with functional dyspepsia. Methods Children (124 cases) with functional dyspepsia in Suzhou Wujiang District Children’s Hospital from April 2022 to December 2024 were randomly divided into control and treatment group, and each group had 62 cases. Children in the control group were po administered with Lacidophilin Granules, 1 g/time, three times daily. Children in the treatment group were po administered with Xiaoer Xiaoshi Granules on the basis of the control group, 1 — 1.5 bag/time for ≤ 7 years, 1.5 bag/time for more than 7 years, three times daily. Children in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, and the symptom relief scores, inflammatory factor indicators IL-6, CRP and TNF-α, gastrointestinal hormone indicators GAS, MOT and VIP, gastric dynamics indicators antral contraction frequency, antral contraction amplitude and gastric emptying rate in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was significantly higher than that in the control group (91.94% vs 77.42%, P < 0.05). After treatment, the symptom scores of children in two groups were significantly reduced (P < 0.05), and the symptom relief scores in the treatment group, including early satiety, feeling full, upper abdominal pain, and feeling burning, were lower than those in the control group (P < 0.05). After treatment, IL-6, CRP, and TNF-α in two groups were significantly reduced (P < 0.05), and inflammatory factors in the treatment group were lower than those in the control group (P < 0.05). After treatment, GAS and MOT in two groups were significantly higher than before treatment, while VIP was lower than before treatment (P < 0.05), and the gastrointestinal hormone indicators in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the gastric antral contraction frequency, gastric antral contraction amplitude, and gastric emptying rate in two groups were higher than before treatment (P < 0.05), and the gastric dynamic indicators in the treatment group were significantly higher than those in the control group (P < 0.05). Conclusion Xiaoer Xiaoshi Granules combined with lactobacillin has a good effect in the treatment of functional dyspepsia in children, promoting the regression of symptoms, reducing inflammatory response, improving gastrointestinal hormones and gastric dynamics.

R975

苏州市医学重点扶持学科（SZFCXK202134）