目的 探讨肉蔻五味丸联合马来酸氟伏沙明片治疗抑郁症的临床疗效。方法 选取2023年5月—2025年4月山东省戴庄医院收治的120例抑郁症患者，将患者按随机数字表法分为对照组和治疗组，每组各60例。对照组口服马来酸氟伏沙明片，2片/次，1次/d。治疗组在对照组基础上口服肉蔻五味丸，12粒/次，3次/d。两组的疗程为8周。比较两组患者的治疗效果、抑郁程度、事件相关电位P300指标、血清指标。结果 对照组的总有效率为85.00%，明显低于治疗组的总有效率96.67%，组间比较差异显著（P＜0.05）。两组治疗后的汉密尔顿抑郁量表24项版（HAMD-24）、抑郁症状快速评估量表（QIDS-SR16）评分均明显降低（P＜0.05），治疗组治疗后的HAMD-24、QIDS-SR16评分低于对照组（P＜0.05）。两组治疗后的PZ、CZ的P300潜伏期明显降低，波幅明显升高（P＜0.05）；治疗组治疗后的PZ、CZ的P300潜伏期低于对照组，波幅高于对照组（P＜0.05）。两组治疗后的碱性髓鞘蛋白（MBP）、胶质纤维酸性蛋白（GFAP）显著降低，神经生长因子（NGF）显著升高（P＜0.05）；治疗组治疗后的MBP、GFAP低于对照组，NGF高于对照组（P＜0.05）。结论 肉蔻五味丸联合马来酸氟伏沙明片可提高抑郁症的疗效，减轻抑郁程度，改善脑部电生理功能，调节神经功能恢复。

Objective To investigate the clinical efficacy of Roukou Wuwei Pills combined with Fluvoxamine Maleate Tablets in treatment of depression. Methods A total of 120 patients with depression admitted to Shandong Daizhuang Hospital from May 2023 to April 2025 were selected and divided into control group and treatment group according to the random number table method, with 60 cases in each group. The control group was administered Fluvoxamine Maleate Tablets orally, 2 tablets/time, once daily. The treatment group received Roukou Wuwei Pills orally on the base of the control group's regimen, 12 pills/time, three times daily. Two groups underwent an 8-week treatment course. The therapeutic efficacy, depression severity, event-related potential P300 indicators, and serum markers were compared between two groups. Results The total effective rate of the control group was 85.00%, significantly lower than the total effective rate of 96.67% in the treatment group, and the difference between two groups was significant (P < 0.05). After treatment, the Hamilton Depression Rating Scale 24 item version (HAMD-24) scores and the Rapid Assessment of Depressive Symptoms Scale (QIDS-SR16) scores in two groups were significantly reduced (P < 0.05). The HAMD-24 and QIDS-SR16 scores in the treatment group were lower than those in the control group (P < 0.05). After treatment, the P300 latency of PZ and CZ were significantly decreased, but the amplitude significantly increased in two groups (P < 0.05). The P300 latency of PZ and CZ in the treatment group was lower than that in the control group after treatment, but the amplitude was higher than that in the control group (P < 0.05). After treatments, the serum levels of MBP and GFAP were significantly reduced, while the levels of NGF were significantly increased (P < 0.05). The serum levels of MBP and GFAP of the treatment group were lower than those of the control group after treatment, but the serum levels of NGF were higher than those of the control group (P < 0.05). Conclusion The combination of Roukou Wuwei Pills and Fluvoxamine Maleate Tablets can improve the efficacy of depression, alleviate depression severity, improve brain electrophysiological function, and regulate neurological function recovery.

R971

山东省医药卫生科技发展计划项目（202203090679）