抑郁症是导致全球疾病负担的主要原因之一，药物治疗仍是最常用且首选的方案。芍药内酯苷可通过调节神经递质的分泌、调节细胞内第二信使系统功能、调节下丘脑–垂体–肾上腺（HPA）轴功能、抑制炎症反应、调控肠道菌群、上调脑源性神经营养因子（BDNF）的表达发挥抗抑郁作用。总结了芍药内酯苷治疗抑郁症的研究进展，为抑郁症的药物临床治疗提供参考。

Depression is one of the leading causes of global disease burden, and pharmacotherapy remains the most commonly used and preferred treatment approach. Albiflorin exerts its antidepressant effects by modulating neurotransmitter secretion, regulating function of intracellular second messenger systems, adjusting the hypothalamic- pituitary - adrenal (HPA) axis function, suppressing inflammatory responses, modulating intestinal microbiota, and upregulating brain-derived neurotrophic factor (BDNF) expression. This article summarizes the research progress on albiflorin in treating depression, providing a reference for clinical pharmacological treatment of depression.

R285.5

上海市虹口区卫生健康委员会中医药科研课题计划项目（HKQGYQY-ZYY-2022-11）