骨质疏松症是一种以骨强度下降和骨折风险增加为特征的骨骼疾病。目前常用的抗骨质疏松药物主要作用于骨代谢的调控，通过促进骨形成、减少骨吸收和骨流失起到治疗效果，但也存在一定的不良反应，且价格昂贵。芹菜素是一种黄酮类化合物，能够促进成骨细胞的增殖、分化，并抑制其凋亡，抑制破骨细胞分化，诱导骨髓间充质干细胞增殖和成骨分化，具有治疗骨质疏松症的潜在价值。总结了芹菜素调控骨代谢治疗骨质疏松症的研究进展，旨在为治疗骨质疏松症的临床和基础研究提供新思路。

Osteoporosis is a bone disease characterized by decreased bone strength and an increased risk of fractures. Currently, commonly used osteoporosis medications primarily target the regulation of bone metabolism, achieving therapeutic effects by promoting bone formation, reducing bone resorption, and minimizing bone loss. However, these treatments also come with certain side effects and are relatively expensive. Apigenin is a flavonoid compound that promotes the proliferation and differentiation of osteoblasts while inhibiting their apoptosis, suppresses osteoclast differentiation, and induces the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells, demonstrating potential therapeutic value for osteoporosis. This article summarizes the research progress on regulation of bone metabolism of apigenin in treatment of osteoporosis, aiming to provide new insights for clinical and fundamental studies on osteoporosis treatment.

R285.5

国家中医临床研究基地开放课题（JD2023SZ23）；江苏省中医药学会雏鹰腾飞项目（CYTF2024044）；昆山高层次卫生人才项目（昆卫[2024]9号）；昆山市中医医院青年科学基金项目（2024QNJJ10）