水飞蓟宾主要来源于菊科植物水飞蓟的干燥果实，是水飞蓟素中的关键成分，具有较强的药理作用。水飞蓟宾在抑制细胞增殖、诱导细胞凋亡、抑制肿瘤侵袭和转移方面得到了广泛认可。另外，水飞蓟宾可以与其他药物联用，可协同增敏、降低不良反应，从而进一步改善患者的生存质量。综述了水飞蓟宾单用和联合用药的抗肿瘤作用研究进展，为水飞蓟宾临床治疗肿瘤提供参考。

Silibinin is derived from the dried fruits of Silybum marianum (L.) Gaertn. in the Asteraceae family. As a key component of silymarin, silybin exhibits potent pharmacological effects. Silymarin has been widely recognized for its ability to inhibit cell proliferation, induce cell apoptosis, and suppress tumor invasion and metastasis. In addition, silibinin can be used in combination with other drugs to synergistically enhance sensitivity and reduce adverse reactions, thereby further improving the quality of life of patients. This article reviews the research progress on the anti-tumor effects of silibinin single use and combination therapy, providing reference for the clinical treatment of tumors with silibinin.

R285.5

国家自然科学基金青年科学基金项目（81402344）；陕西省自然科学基础研究计划面上项目（2023JC-YB-745）；秦创原中医药产业创新聚集区项目（L2024-QCY-ZYYJJQ-X143）