目的 观察龙鹿丸联合尿促性素治疗排卵障碍性不孕症的临床疗效。方法 选取2023年1月—2024年11月在郑州陇海妇产医院治疗的排卵障碍性不孕症患者82例，利用随机数字表法将入组患者分为对照组和治疗组，每组各41例。对照组在经期第5天肌内注射注射用尿促性素，首剂量75 U/d，1次/d。连续治疗1周后根据患者雌激素、卵泡发育状况调整剂量。治疗组在对照组基础上口服龙鹿丸，1 g/次，3次/d。两组均持续治疗3个月经周期。观察两组患者临床疗效，比较治疗前后两组患者中医证候积分、主卵泡直径和子宫内膜厚度，子宫动脉阻力指数（RI）和搏动指数（PI），性激素黄体生成素（LH）、孕酮（P）、雌二醇（E₂）和卵泡刺激素（FSH）水平，及妊娠率与排卵率。结果 治疗后，治疗组总有效率（95.12%）明显优于对照组80.49%（P＜0.05）。治疗后，两组中医证候积分降低（P＜0.05）；治疗组积分较对照组明显更低（P＜0.05）。治疗3个月后，两组患者主卵泡直径、子宫内膜厚度均明显升高（P＜0.05），且治疗组主卵泡直径、子宫内膜厚度较对照组明显升高（P＜0.05）。治疗3个月后，两组RI、PI均明显下降（P＜0.05），且治疗组患者RI、PI较对照组降低更明显（P＜0.05）。治疗3个月后，两组患者LH、FSH、E₂、P水平均明显升高（P＜0.05），且治疗组性激素水平较对照组升高更明显（P＜0.05）。与对照组相比，治疗后治疗组排卵率与妊娠率均明显升高（P＜0.05）。结论 龙鹿丸与尿促性素联合治疗排障卵碍性不孕症患者，治疗效果更好，利于改善性激素、子宫内环境等异常状态，提升排卵率与妊娠率。

Objective To observe the effects of Longhu Pills combined with menotropins in treatment of ovulatory disorder infertility. Methods Patients (82 cases) with ovulatory disorder infertility in Zhengzhou Longhai Maternity and Gynecology Hospital from January 2023 to November 2024 were divided into control group and treatment group by the random number table method, with 41 cases in each group. Patient in control group were injected intramuscularly with Menotropins for injection on the 5th d of menstruation, with the first dose of 75 units/d, once daily, after 1 week of continuous treatment, the dose was adjusted according to the patient’s estrogen and follicular development status. Patient in the treatment group were po administered with Longlu Pills on the basis of the control group, 1 g/time, three times daily. Patient in two groups were treated for 3 menstrual cycles. After treatment, the clinical evaluations were evaluated, and the TCM syndrome scores, follicles, endometrium, RI and PI of uterine artery blood flow, the levels of sex hormones LH, FSH, E₂ and P, pregnancy and ovulation rates in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group (95.12%) was significantly better than that in the control group (80.49%, P< 0.05). After the treatment, the TCM syndrome scores of the two groups decreased (P < 0.05). The score of the treatment group was significantly lower than that of the control group (P < 0.05). After 3 months of treatment, the main follicle diameter and endometrial thickness in two groups were significantly increased (P < 0.05), and the main follicle diameter and endometrial thickness of the treatment group were significantly higher than those of the control group (P < 0.05). After 3 months of treatment, RI and PI were significantly decreased in two groups (P < 0.05), and RI and PI were decreased more significantly in the treatment group than in the control group (P < 0.05). After 3 months of treatment, the levels of LH, FSH, E₂, and P in two groups were significantly increased (P < 0.05), and the levels of sex hormones in the treatment group were more significantly increased than those in the control group (P < 0.05). Compared with the control group, the ovulation rate and pregnancy rate in the treatment group were significantly increased after treatment (P < 0.05). Conclusion Longlu Pills combined with menotropins achieves better therapeutic effects in patients with ovulatory disorder infertility, effectively improving sex hormone levels, uterine environment, and enhancing ovulation and pregnancy rates.

R984

河南省医学科技攻关计划软科学项目（LHGj20210373）