目的 观察根痛平胶囊联合牛痘疫苗接种家兔炎症皮肤提取物片治疗神经根型颈椎病的临床疗效。方法 纳入中国人民解放军总医院第七医学中心2023年10月—2024年10月接收的神经根型颈椎病患者98例。将患者按随机数字表法分为对照组和治疗组，每组49例。对照组早晚口服牛痘疫苗接种家兔炎症皮肤提取物片，4片/d。治疗组在对照组基础上口服根痛平胶囊，6粒/次，2次/d。两组持续治疗1个月。对比两组临床疗效、疼痛程度、颈椎功能、生活质量、血流动力学指标、血清炎症反应指标。结果 治疗组的总有效率比对照组更高（P＜0.05）。治疗后，两组的疼痛视觉模拟评分（VAS）、颈椎病临床评价量表（CASCS）、颈椎病功能障碍指数（NDI）评分下降（P＜0.05），且治疗组的VAS、CASCS、NDI评分低于对照组（P＜0.05）。治疗后，两组生活质量简易量表（SF-36）各维度评分和总分均升高（P＜0.05），且治疗组SF-36各维度评分和总分高于对照组（P＜0.05）。治疗后，两组血管阻力指数（RI）下降，收缩期峰值流速（PSV）、血流流速（V_m）升高（P＜0.05），且治疗组RI低于对照组，PSV、V_m高于对照组（P＜0.05）。治疗后，两组血清白细胞介素（IL）-1β、IL-6、肿瘤坏死因子-α（TNF-α）、γ-干扰素（IFN-γ）水平下降（P＜0.05），且治疗组血清IL-1β、IL-6、TNF-α、IFN-γ水平低于对照组（P＜0.05）。结论 根痛平胶囊联合牛痘疫苗接种家兔炎症皮肤提取物片治疗神经根型颈椎病，可提高临床疗效，改善颈椎功能和血流动力学，减轻疼痛程度和炎症反应，有助于提高患者生活质量。

Objective To observe the clinical efficacy of Gentongping Capsules combine with Neurotropin Tablets in treatment of cervical spondylotic radiculopathy. Methods 98 Patients with cervical spondylotic radiculopathy who were admitted to the Seventh Medical Center, Chinese PLA General Hospital from October 2023 to October 2024 were selected. According to the random number table method, patients were divided into control group and treatment group, with 49 cases in each group. The control group was po administered with Neurotropin Tablets in the morning and evening, 4 tablets/d. The treatment group was po administered with Gentongping Capsules on the basis of the control group, 6 capsules/time, twice daily. Two groups were treated continuously for one month. The clinical efficacy, pain level, cervical function, quality of life, hemodynamic indicators, and serum inflammatory response indicators were compared between two groups. Results The total effective rate of the treatment group was higher than that of the control group (P < 0.05). After treatment, the VAS, CASCS, and NDI scores of two groups decreased (P < 0.05), and the VAS, CASCS, and NDI scores of the treatment group were lower than those of the control group (P< 0.05). After treatment, the scores and total scores of each dimension of the Short Form of Life (SF-36) in two groups increased (P < 0.05), and the scores and total scores of each dimension of SF-36 in the treatment group were higher than those in the control group (P < 0.05). After treatment, the vascular resistance index (RI) of two groups decreased, while the peak systolic velocity (PSV) and blood flow velocity (V_m) increased (P < 0.05). The RI of the treatment group was lower than that of the control group, while the PSV and V_m were higher than those of the control group (P < 0.05). After treatment, the serum levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) decreased in two groups (P < 0.05), and the serum levels of IL-1β, IL-6, TNF-α, and IFN-γ in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Gentongping Capsules and Neurotropin Tablets can improve clinical efficacy, enhance cervical function and hemodynamics, alleviate pain and inflammatory reactions, and contribute to improve the quality of life of patients with cervical spondylotic radiculopathy.

R971

北京市卫生健康委员会首都卫生发展科研专项（首发2022-2-5085）