支气管哮喘是一种由多种细胞和介质参与的慢性气道炎症性疾病，采用药物治疗时存在药物耐受、复发和不良反应风险。葛根素是从葛根中提取的主要异黄酮类化合物，可通过减轻炎性损伤、抑制支气管上皮细胞凋亡、改善凝血功能、调节自噬体-溶酶体平衡、调节肠道菌群结构发挥抗支气管哮喘作用。总结了葛根素治疗支气管哮喘的药理作用研究进展，为葛根素的临床应用提供依据。

Bronchial asthma is a chronic airway inflammatory disease involving multiple cells and mediators, and there is a risk of drug tolerance, recurrence, and adverse reactions when treated with medication. Puerarin is the main flavonoid compound extracted from Puerariae Radix, and puerarin can exert anti-bronchial asthma effects by reducing inflammatory damage, inhibiting apoptosis of bronchial epithelial cells, improving coagulation function, regulating autophagosome lysosome balance, and modulating intestinal flora structure. This article summarizes the pharmacological research progress of puerarin in treatment of bronchial asthma, providing a basis for the clinical application of puerarin.

R286.4

重庆市大足区科技发展项目（DZKJ2024JSYJ-KWXM1025）