急慢性肾损伤是由多种因素导致肾功能急性或持续性减退的综合征，临床常用治疗药物可延缓病情进展，但疗效有限，且存在不良反应。人参皂苷Rb₁为人参中提取的主要活性皂苷，可通过减轻氧化应激反应、降低炎性损伤、降低肾组织细胞凋亡、抑制肾组织纤维化、延缓血管钙化防治急慢性肾损伤，保护肾功能。总结了人参皂苷Rb₁防治急慢性肾损伤的药理作用研究进展，为急慢性肾损伤的干预提供新的策略。

Acute and chronic kidney injury is a syndrome characterized by acute or sustained decline in kidney function caused by multiple factors. Commonly used clinical treatment drugs can delay the progression of the disease, but the efficacy is limited and there are adverse reactions. Ginsenoside Rb₁ is the main active saponin extracted from Ginseng Radix et Rhizoma, which can prevent and treat acute and chronic kidney injury and protect kidney function by reducing oxidative stress response, reducing inflammatory damage, decreasing renal tissue cell apoptosis, inhibiting renal tissue fibrosis, and delaying vascular calcification. This article summarizes the pharmacological effects of ginsenoside Rb₁ in preventing and treating acute and chronic kidney injury, providing new strategies for intervention in acute and chronic kidney injury.

R287.5

内蒙古公立医院科研联合基金科技项目（2024GLLH0347）