基因多态性是造成抗血小板药物治疗效果个体差异的主要原因之一。心脑血管疾病患者DNA甲基化的异常可能会影响抗血小板药物的代谢过程，产生药物抵抗现象。DNA甲基化影响阿司匹林、氯吡格雷、阿司匹林与氯吡格雷联合、替格瑞洛以及活血类中药抗血小板反应。总结了DNA甲基化对心脑血管疾病患者抗血小板药物反应的影响，为心脑血管疾病个体化治疗提供参考。

Genetic polymorphism is one of the primary causes of individual differences in the efficacy of antiplatelet drug therapy. Abnormal DNA methylation in patients with cardiovascular and cerebrovascular diseases may affect the metabolic process of antiplatelet drugs, leading to drug resistance. DNA methylation influences the antiplatelet responses to aspirin, clopidogrel, aspirin combined with clopidogrel, ticagrelor, and Blood-activating traditional Chinese medicines. This article summarizes the impact of DNA methylation on the antiplatelet drug response in patients with cardiovascular and cerebrovascular diseases, providing a reference for individualized treatment for cardiovascular and cerebrovascular diseases.

R972

湖南省教育厅科学研究项目（23C0277）；邵阳学院教学改革研究项目（2022JG21）；邵阳学院附属第一医院科学研究项目（25FY1011）