肿瘤细胞通过糖代谢重编程获得能量和生物合成前体，以支撑其无限增殖、侵袭转移、应激耐受等恶性生物学行为，该代谢特征已成为肿瘤治疗的关键靶点。中药因生物活性广泛、毒性低等优势，在肿瘤治疗领域展现出良好应用场景，但存在水溶性差、生物利用度低、靶向性不足等瓶颈。纳米技术可有效解决上述问题，实现药物的精准递送和疗效增效。综述了中药纳米制剂调控肿瘤糖代谢的主要药理策略，包括阻断葡萄糖转运蛋白功能、降低关键酶活性以及调控肿瘤微环境因素，旨在为靶向代谢的抗肿瘤疗法提供参考。

Tumor cells obtain energy and biosynthetic precursors through glucose metabolic reprogramming to support their malignant biological behaviors, such as unlimited proliferation, invasion and metastasis, and stress tolerance. This metabolic characteristic has become a key target for tumor therapy. Traditional Chinese medicine has shown promising application prospects in tumor therapy due to its advantages of broad biological activities and low toxicity, but it faces challenges including poor water solubility, low bioavailability and insufficient targeting ability. Nanotechnology can effectively solve the above problems, achieve precise drug delivery and enhance therapeutic efficacy. This article summarizes the main pharmacological strategies of traditional Chinese medicine nanopreparations in regulating tumor glucose metabolism, including blocking glucose transporter function, reducing key enzyme activity, and modulating tumor microenvironment factors, aiming to provide reference for targeted metabolism based anti-tumor therapies.

R283.6

天津市教委科研计划项目（2024ZD003，2023KJ136）