目的 探寻青娥丸联合骨化三醇软胶囊治疗绝经后骨质疏松症的疗效观察，为优化绝经后骨质疏松症治疗路径、提高患者整体获益提供新的治疗选择。方法 回顾性选取江苏大学附属医院2023年5月—2025年5月收治的100例绝经后骨质疏松症患者，根据用药方案差异分为对照组（50例）和治疗组（50例）。对照组给予骨化三醇软胶囊，0.25 μg/次，2次/d。治疗组在对照组治疗基础上给予青娥丸，9 g/次，2次/d。两组均连续治疗3个月。观察两组的临床疗效，比较治疗前后骨代谢指标、骨密度的变化。结果 治疗后，治疗组患者总有效率是98.00%，显著高于对照组的80.00%（P＜0.05）。治疗后，两组患者骨钙素（BGP）、总Ⅰ型胶原氨基端延长肽（PINP）较治疗前升高，I型胶原羧基端肽β特殊序列（β-CTX）、甲状旁腺素（PTH）水平与治疗前比较均降低（P＜0.05），且治疗后治疗组BGP、PINP高于对照组，β-CTX、PTH水平较对照组更低（P＜0.05）。治疗后两组腰椎、股骨及粗隆间骨密度与同组治疗前比较均上升（P＜0.05），且治疗后治疗组腰椎、股骨及粗隆间骨密度均高于对照组（P＜0.05）。结论 青娥丸与骨化三醇软胶囊联用可为绝经后骨质疏松症患者产生多重积极影响，该方案在增强疗效的同时，可促进良性骨代谢及提升骨密度，展现出较高的临床应用价值。

Objective To explore the therapeutic effect of Qing’e Pills combined with calcitriol in treatment of postmenopausal osteoporosis, and to provide new treatment options for optimizing the treatment pathway of postmenopausal osteoporosis and improving the overall benefits of patients. Methods A retrospective selection was made of 100 postmenopausal patients with osteoporosis who were admitted to the Affiliated Hospital of Jiangsu University from May 2023 to May 2025. These patients were divided into control group (50 cases) and treatment group (50 cases) based on the differences in medication regimens. Patients in control group were po administered with Calcitriol Soft Capsules, 0.25 μg/time, twice daily. Patients in treatment group were po administered with Qing’e Pills on the basis of control group, 9 g/time, twice daily. Both groups were treated continuously for 3 months. The clinical efficacy of two groups was observed, and the changes in bone metabolism indicators and bone density before and after treatment were compared. Results After treatment, the total effective rate of treatment group was 98.00%, significantly higher than that of control group (80.00%) (P < 0.05). After treatment, the levels of osteocalcin (BGP) and total type I collagen amino-terminal propeptide (PINP) in both groups increased compared to before treatment, but the levels of type I collagen carboxy-terminal peptide β-specific sequence (β-CTX) and parathyroid hormone (PTH) decreased compared to before treatment (P < 0.05). Moreover, after treatment, the levels of BGP and PINP in treatment group were higher than those in control group, and the levels of β-CTX and PTH were lower than those in control group (P < 0.05). After treatment, the bone density of the lumbar spine, femur, and intertrochanteric region in both groups increased compared to before treatment (P < 0.05), and the bone density of the lumbar spine, femur, and intertrochanteric region in treatment group was higher than that in control group (P < 0.05). Conclusion The combination of Qing’e Pills and Calcitriol Soft Capsules can have multiple positive effects on postmenopausal osteoporosis patients. This treatment plan not only enhances the therapeutic effect but also promotes benign bone metabolism and increases bone density, demonstrating high clinical application value.

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