目的 探讨解郁安神颗粒联合富马酸喹硫平片治疗轻中度抑郁症的临床疗效。方法 收集天津市北辰医院在2023年2月—2025年10月收治的轻中度抑郁症患者共计102例，所有患者以随机数字表法分为对照组和治疗组，各有51例。对照组患者口服富马酸喹硫平片，2次/d，起始剂量1片/次，然后每日每次增加1片，维持剂量3～6片/次。治疗组在对照组基础上开水冲服解郁安神颗粒，1袋/次，2次/d。两组持续治疗1个月。比较两组患者的治疗效果、抑郁程度、躯体症状、睡眠质量、事件相关电位P300参数和血清指标。结果 对照组的总有效率为76.47%，治疗组的总有效率为92.16%，组间比较差异显著（P＜0.05）。两组治疗后的汉密尔顿抑郁量表17项版本（HAMD-17）、躯体化症状自评量表（SSS）、睡眠状况自评量表（SRSS）评分明显降低（P＜0.05），治疗组治疗后的HAMD-17、SSS、SRSS评分均低于对照组（P＜0.05）。两组治疗后PZ位点的P300潜伏期明显降低，波幅明显升高（P＜0.05）；治疗组治疗后的PZ位点的P300潜伏期低于对照组，波幅高于对照组（P＜0.05）。两组治疗后的血清神经细胞黏附分子（NCAM）、脂蛋白相关磷脂酶A2（Lp-PLA2）水平明显降低，血清转录因子叉头框蛋白O1（FOXO1）水平明显升高（P＜0.05）；治疗组的血清NCAM、Lp-PLA2水平低于对照组，血清FOXO1水平高于对照组（P＜0.05）。结论 解郁安神颗粒联合富马酸喹硫平片可提高轻中度抑郁症的治疗效果，减轻抑郁症状和躯体化症状，改善睡眠质量，提高认知功能和降低神经炎性损伤。

Objective To investigate the clinical efficacy of Jieyu Anshen Granules combined with Quetiapine Fumarate Tablets in treatment of mild to moderate depression. Methods A total of 102 patients with mild to moderate depression admitted to Tianjin Beichen Hospital from February 2023 to October 2025 were enrolled. All patients were divided into control group and treatment group using a random number table, with 51 cases in each group. The control group received oral Quetiapine Fumarate Tablets at a starting dose of 1 tablets, twice daily, with a daily increment of 1 tablets per dose, and a maintenance dose of 3-6 tablets per time. The treatment group received po administered with Jieyu Anshen Granules dissolved in hot water on base of the control group regimen, at 1 bag per time, twice daily. Two groups were treated for one month. The therapeutic effects, depression severity, somatic symptoms, sleep quality, event-related potential P300 parameters, and serum indicators were compared between two groups. Results The total effective rate of the control group was 76.47%, while that of the treatment group was 92.16%, with a significant difference between two groups (P < 0.05). After treatment, the 17-item version of the Hamilton Depression Scale (HAMD-17), Somatic Symptom Self-Rating Scale (SSS), and Sleep Status Self-Rating Scale (SRSS) scores were significantly reduced in two groups (P < 0.05), and the HAMD-17, SSS, and SRSS scores in the treatment group were all lower than those of the control group (P < 0.05). After treatment, the P300 latency at the PZ site significantly decreased, but amplitude significantly increased in two groups (P < 0.05). After treatment, the P300 latency at the PZ site in treatment group was lower than that of the control group, but the amplitude was higher (P < 0.05). After treatment, serum levels of neural cell adhesion molecule (NCAM) and lipoprotein-associated phospholipase A2 (Lp-PLA2) in two groups significantly decreased, but serum levels of transcription factor forkhead box O1 (FOXO1) significantly increased (P < 0.05). Serum levels of NCAM and Lp-PLA2 in the treatment group were lower than those in the control group, but serum levels of FOXO1 were higher than those of the control group (P < 0.05). Conclusion The combination of Jieyu Anshen Granules and Quetiapine Fumarate Tablets can improve the therapeutic effect of mild to moderate depression, alleviate depressive symptoms and somatization symptoms, improve sleep quality, enhance cognitive function, and reduce neuroinflammatory damage.

R971

天津市北辰区科技计划项目（SHGY-2020003）