目的 建立电感耦合等离子体原子发射光谱（ICP-AES）法测定枸橼酸铋钾胶囊、枸橼酸铋钾颗粒、枸橼酸铋钾片中铋、钾。方法 采用ICP-AES法，等离子体功率：1 400 W；载气体积流量：0.7 L/min；冷却气：14 L/min；辅助气：0.3 L/min；蠕动泵转速：1.00 mL/min；观测模式：Radial；测量次数：3次；铋的分析谱线：233.061 nm；钾的分析谱线：766.490 nm。结果 铋在1.0～20.0µg/mL、钾在0.4～8.0 µg/mL的线性关系良好。铋、钾的平均回收率分别为100.83%、100.13%，RSD值分别为1.4%、0.4%。结论 方法操作简便，精密度高，准确性好，可用于枸橼酸铋钾制剂的质量评价和控制。

Objective To establish an inductively coupled plasma atomic emission spectrometry (ICP-AES) method to determine bismuth and potassium in Bismuth Potassium Citrate Capsules, Granules, and Tablets. Methods ICP-AES method was carried on, and the conditions were as following: plasma power 1 400 W, carrier gas flow rate 0.7 L/min, cooling gas 14 L/min, auxiliary gas 0.3 L/min, peristaltic pump speed 1.00 mL/min, observation mode radial, measurement repetitions 3 times, analytical spectral line 233.061 nm for bismuth, and analytical spectral line 766.490 nm for potassium. Results There were good linear relationships in the ranges of 1.0-20.0 µg/mL of bismuth and 0.4-8.0 µg/mL of potassium. The average recovery rates of bismuth and potassium were 100.83% and 100.13%, with RSD values of 1.4% and 0.4%. Conclusion The method is easy to operate, has high precision, and good accuracy, and can be used for quality evaluation and control for bismuth potassium citrate preparations.

R927.2

江苏省药品抽检计划项目（苏药监稽〔2024〕33号）