脑缺血再灌注损伤的病理过程复杂，目前临床用于治疗脑缺血再灌注损伤的神经保护药物种类有限。二苯乙烯苷可通过抗氧化活性、抗炎活性、调控细胞凋亡、维持线粒体稳态、促进神经修复、促进血管新生、调控神经递质分泌发挥脑缺血再灌注损伤保护作用。总结了二苯乙烯苷改善脑缺血再灌注损伤的药理作用研究进展，旨在为二苯乙烯苷的研究和开发提供参考。

Ischemic stroke is the most common cerebrovascular disease in clinical practice, and cerebral ischemia-reperfusion injury caused by blood flow recovery is an important pathological process that affects the prognosis of patients. Diethylbenzene glycoside can exert protective effects against cerebral ischemia-reperfusion injury through multiple pathways, including antioxidant activity, inhibition of inflammatory response, regulation of cell apoptosis, maintenance of mitochondrial homeostasis, promotion of neural repair and angiogenesis, and regulation of neurotransmitter secretion. This article reviews the pharmacological effects and mechanisms of stilbene glycoside in preventing and treating cerebral ischemia-reperfusion injury, aiming to provide reference for further research and development of stilbene glycoside.

R285.5

凉山州科技计划重点研发项目（21ZDYF0182）