近年来，痛风和高尿酸血症的发病率、患病率逐年增加。临床常用治疗痛风的药物都存在不同程度的不良反应，患者难以长期服用，且停药后易复发。高良姜及其活性成分高良姜素等可通过抑制黄嘌呤氧化酶活性、调节肾脏尿酸转运蛋白、改善肠-肾轴功能、抗炎和抗氧化应激发挥降尿酸作用。综述了高良姜及其活性成分降尿酸的药理作用研究进展，为高良姜防治高尿酸血症应用提供参考。

In recent years, the incidence and prevalence rates of gout and hyperuricemia have been increasing annually. Commonly used clinical medications for treating gout all exhibit varying degrees of adverse effects, making long-term administration difficult for patients, and symptoms often recur upon discontinuation. Alpiniae Officinarum Rhizoma and its active component galangin can reduce uric acid levels by inhibiting xanthine oxidase activity, regulating renal urate transport proteins, improving intestinal-renal axis function, and exerting anti-inflammatory and antioxidant stress effects. This article reviews the pharmacological research progress on the uric acid-lowering effects of Alpiniae Officinarum Rhizoma and its active components, providing a reference for the application of Alpiniae Officinarum Rhizoma in prevention and treatment of hyperuricemia.

R285.5

广东省自然科学基金项目（2021A1515110858，2023A1515011116）；广东省研究生教育创新计划项目（4SG24170G）；广东省本科高校教学质量与教学改革工程建设项目（4SG25100P）