目的 观察复方牙痛酊联合西地碘含片治疗儿童牙龈炎的临床疗效。方法 选取2024年2月—2026年2月天津市口腔医院收治的90例牙龈炎患儿，按照随机数字表法分为对照组与治疗组，每组各45例。对照组患儿给予西地碘含片含服，1片/次，3次/d。治疗组在对照组的基础上给予复方牙痛酊涂抹，采用棉球蘸取适量药液涂擦患处，3次/d。两组用药7 d。观察两组的临床疗效，比较两组中医证候积分、菌斑指数评分（PLI）、龈沟出血指数评分（SBI）、牙龈指数评分（GI）、白细胞介素-1β（IL-1β）、细胞间黏附分子-1（ICAM-1）、转化生长因子-β1（TGF-β1）、基质金属蛋白酶抑制因子-2（TIMP-2）水平。结果 治疗后，治疗组患儿总有效率95.56%显著高于对照组80.00%（P＜0.05）。治疗后，两组患儿牙龈肿痛积分、口臭积分、口干积分、便秘积分均较同组治疗前显著降低（P＜0.05）；治疗后与对照组对比，治疗组牙龈肿痛积分、口臭积分、口干积分、便秘积分均降低（P＜0.05）。治疗后，两组牙龈炎患儿GI评分、PLI评分、SBI评分均较同组治疗前显著降低（P＜0.05）；治疗后与对照组对比，治疗组GI评分、PLI评分、SBI评分均降低（P＜0.05）。治疗后，两组血清IL-1β、ICAM-1较同组治疗前显著降低，而TGF-β1、TIMP-2水平升高（P＜0.05）；治疗后与对照组对比，治疗组患儿IL-1β、ICAM-1水平均降低，且治疗组的TGF-β1、TIMP-2水平均升高（P＜0.05）。结论 复方牙痛酊与西地碘含片协同治疗儿童牙龈炎效果明显，可有效改善患儿牙龈及牙周情况，减弱牙龈的炎性反应，且药物安全，值得借鉴与应用。

Objective To observe the clinical efficacy of Compound Yatong Tincture combined with cydiodine in treatment of gingivitis in children. Methods From February 2024 to February 2026, 90 children with gingivitis admitted to Tianjin Stomatological Hospital were selected and divided into control group and treatment group according to random number table method, with 45 cases in each group. Children in control group were given Cydiodine Buccal Tablets for swallowing, 1 tablet/time, 3 times daily. Children in treatment group were given Compound Yatong Tincture for application on the affected area, using cotton balls to dip an appropriate amount of medicine and apply it to the affected area, 3 times daily. Both groups were treated for 7 d. The clinical efficacy of two groups was observed, and TCM syndrome scores, plaque index score (PLI), gingival bleeding index score (SBI), gingival index score (GI), interleukin-1β (IL-1β), intercellular adhesion molecule-1 (ICAM-1), transforming growth factor-β1 (TGF-β1), and matrix metalloproteinase inhibitor-2 (TIMP-2) levels of two groups were compared. Results After treatment, the total effective rate of treatment group (95.56%) was significantly higher than that of control group (80.00%) (P < 0.05). After treatment, the scores of gingival swelling and pain, halitosis, dry mouth, and constipation in both groups were significantly lower than those before treatment in same group (P< 0.05). After treatment, compared with control group, the scores of gingival swelling and pain, halitosis, dry mouth, and constipation in treatment group were all decreased (P < 0.05). After treatment, GI scores, PLI scores, and SBI scores of gingivitis patients in both groups were significantly lower than those before treatment in same group (P < 0.05). After treatment, compared with control group, GI scores, PLI scores, and SBI scores of treatment group were all decreased (P < 0.05). After treatment, the serum levels of IL-1β and ICAM-1 in both groups were significantly lower than those before treatment in same group, while the levels of TGF-β1 and TIMP-2 were increased (P < 0.05). After treatment, compared with control group, the levels of IL-1β and ICAM-1 in treatment group were all decreased, and the levels of TGF-β1 and TIMP-2 in treatment group were all increased (P < 0.05). Conclusion The combined treatment of Compound Yatong Tincture and cydiodine for children’s gingivitis has a significant effect. It can effectively improve condition of the children’s gums and periodontium, reduce the inflammatory response of gums, and the drugs are safe, making it worthy of reference and application.

R988.2