目的 探讨鲜益母草胶囊联合卡贝缩宫素注射液治疗产后出血的临床疗效。方法 选取武汉大学中南医院2023年3月—2025年12月收治的150例产后出血患者的临床资料，按照治疗方案将患者分为对照组和治疗组，每组75例。对照组一次性注射卡贝缩宫素注射液。治疗组在对照组治疗基础上服用鲜益母草胶囊，4粒/次，3次/d，持续治疗7 d。比较两组的治愈率、出血情况、血流动力学指标、凝血功能指标。结果 对照组的治愈率为82.67%，治疗组的治愈率为93.33%，组间比较差异有统计学意义（P＜0.05）。治疗组患者总出血量、止血时间、收缩持续时间均明显低于对照组（P＜0.05）。两组治疗后的子宫血管化-血流指数（VFI）明显降低，搏动指数（PI）、收缩期峰值流速（PSV）明显升高（P＜0.05）；治疗组治疗后的VFI低于对照组，PI、PSV均高于对照组（P＜0.05）。两组治疗后的D-二聚体（D-D）、凝血酶原时间（PT）均显著降低，纤维蛋白原（FIB）显著升高（P＜0.05）；治疗组治疗后的D-D、PT均低于对照组，FIB高于对照组（P＜0.05）。结论 鲜益母草胶囊联合卡贝缩宫素注射液可提高产后出血的疗效，提高止血效果，改善凝血功能和子宫血流动力学水平。

Objective To investigate the clinical efficacy of Xianyimucao Capsules combined with Carbetocin Injection in treatment of postpartum hemorrhage. Methods The clinical data of 150 postpartum hemorrhage patients admitted to Zhongnan Hospital of Wuhan University from March 2023 to December 2025 were selected, and all patients were divided into control group and treatment group according to different treatment regimens, with 75 cases in each group. The control group received a single intravenous injection of Carbetocin Injection. The treatment group were po administered with Xianyimucao Capsules in addition to the control group's treatment, with a dosage of 4 capsules per time, 3 times daily, for a continuous treatment period of 7 days. The cure rates, bleeding conditions, hemodynamic indicators, and coagulation function indicators were compared between two groups. Results The cure rate of the control group was 82.67%, while the cure rate of the treatment group was 93.33%, and the difference between two groups was statistically significant (P < 0.05). The total bleeding volume, hemostasis time, and duration of contraction in the treatment group were significantly lower than those in the control group (P <0.05). After treatment, the uterine vascularization - blood flow index (VFI) of two groups was significantly decreased, while the pulsatility index (PI) and peak systolic velocity (PSV) were significantly increased (P<0.05). After treatment, the VFI of the treatment group was lower than that of the control group, while the PI and PSV were higher than those of the control group (P <0.05). After treatment, D-dimer (D-D) and prothrombin time (PT) were significantly reduced in two groups, while fibrinogen (FIB) was significantly increased (P <0.05). After treatment, the D-D and PT of the treatment group were lower than those of the control group, while FIB was higher than that of the control group (P<0.05). Conclusion The combination of Xianyimucao Capsules and Carbetocin Injection can improve the efficacy of postpartum hemorrhage, enhance hemostasis, improve coagulation function and uterine hemodynamics.

R984

国家自然科学基金资助项目（82103620）