骨缺损修复是一个多细胞、多因子参与的复杂过程，治疗药物难以满足临床需求。槲皮素可通过调控骨代谢稳态、调控细胞凋亡和自噬、促进血管生成、调控免疫炎症微环境、拮抗氧化应激损伤促进骨缺损修复。总结了槲皮素促进骨缺损修复的药理作用研究进展，为其在骨组织工程中的应用提供参考。

Bone defect repair is a complex process involving multiple cells and factors, making it difficult for therapeutic drugs to meet clinical demands. Quercetin can promote bone defect repair by regulating bone metabolism homeostasis, modulating apoptosis and autophagy, stimulating angiogenesis, regulating the immune-inflammatory microenvironment, and counteracting oxidative stress damage. This article summarizes the pharmacological research progress on quercetin’s role in promoting bone defect repair, providing a reference for its application in bone tissue engineering.

R286.7

重庆市大足区科技发展项目（DZKJ2024JSYJ-KWXM1056）